The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats
Joint Authors
Abu Shawq, Asma M.
Oda, Samah S.
al-Bulayhi, Samar S.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 57, Issue 1 (30 Apr. 2018), pp.148-160, 13 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2018-04-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study was designed to evaluate the effect of Nano-Zinc (N-Zn) and Zinc (Zn) against copper (Cu) toxicosis in rats.
Sixty male albino rats were randomly divided into 6 groups (n=10); control group, Cu-treated group: orally received CuSo4 (100 mg/kg bwt/day ), N-Zn-treated group: intraperitoneally (IP) injected with N-ZnO (5 mg/kg bwt/day), Zn-treated group: IP injected with ZnO (5 mg/kg bwt/day), Cu+N-Zn - and Cu+Zn -treated groups received the same previous doses and routes.
All the experimental treatments were given 3 times / week and continued for eight weeks.
Results showed that Cu- treated group caused a significant decrease in body weight and a significant increase in relative liver and kidney weights.
Also, Cu caused a significant decrease in red blood cells (RBCs) count, hemoglobin (Hb) concentration, mean corpuscular hemoglobin concentration (MCHC) and platelets count with a significant increase in mean corpuscular volume (MCV) without any changes in leukocytic count.
Biochemical analysis showed a significant elevation in serum liver enzymes, total and indirect bilirubin with a significant decrease in serum levels of total proteins and albumin.
Also, there was a significant elevation in serum urea and creatinine levels.
Cu induced a significant increase in renal and hepatic malondialdhyde (MDA) and a significant decrease in reduced glutathione (GSH).
Histopathologically, Cu revealed severe degenerative and necrotic lesions in the livers and kidneys.
N-Zn and Zn- treatments attenuated Cu-induced oxidative damage, alterations in the liver and kidney function tests and histopathology.
Moreover, Zn treatment showed better protection against Cu-induced toxicity as compared to N-Zn.
American Psychological Association (APA)
Abu Shawq, Asma M.& Oda, Samah S.& al-Bulayhi, Samar S.. 2018. The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats. Alexandria Journal of Veterinary Sciences،Vol. 57, no. 1, pp.148-160.
https://search.emarefa.net/detail/BIM-1330085
Modern Language Association (MLA)
Abu Shawq, Asma M.…[et al.]. The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats. Alexandria Journal of Veterinary Sciences Vol. 57, no. 1 (Apr. 2018), pp.148-160.
https://search.emarefa.net/detail/BIM-1330085
American Medical Association (AMA)
Abu Shawq, Asma M.& Oda, Samah S.& al-Bulayhi, Samar S.. The potential ameliorative effect of Nano-zinc and zinc against copper hepatorenal toxicosis in rats. Alexandria Journal of Veterinary Sciences. 2018. Vol. 57, no. 1, pp.148-160.
https://search.emarefa.net/detail/BIM-1330085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 157-160
Record ID
BIM-1330085