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Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients
المؤلفون المشاركون
Ibrahim, Basmah O.
Ahmad, Husayni M.
Umar, Hamdi H.
Tawfiq, Jamal A.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 25، العدد 1 (31 مارس/آذار 2022)، ص ص. 80-91، 12ص.
الناشر
تاريخ النشر
2022-03-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : vascular calcification (VC) plays a major role in cardiovascular disease (CVD), which is one of the main causes of mortality in patients with chronic kidney disease (CKD).
during the early stages of CKD, fibroblast growth factor-23 (FGF-23) levels increase to keep serum phosphorus within the normal range.
FGF23 may be associated with death and cardiovascular events in CKD patients.
aim : the study aimed at early detection of breast arterial calcification (BAC) and higher levels of FGF-23 as indicators of systemic VC in patients with different stages of CKD.
methodology : the patients were divided into 3 groups ; representing stages 2, 3 & 4 of CKD women, and the 4th group was considered as a control group.
the selected participants were subjected to history taking, mammogram to detect BAC and biochemical assessment of lipid profile, serum creatinine, Mg, P, Ca, PTH and FGF23.
Results : the presence of BAC in about 81.8% of stage 4 CKD patients compared with 50% in stage 3 CKD, also in the majority of stage 4 CKD patients had high FGF-23.
receiver operator characteristic (ROC) curve analysis showed serum FGF-23 as a potential predictor of BAC (AUC = 0.874) in CKD patients at the cut-off point of 77.5 ng / ml (sensitivity 78%, specificity 76%).
Conclusion : although it is difficult to determine the definite stage at which the risk of VC begins but, in our study, it began late in stage 2 CKD, gradually increased prevalence through stage 3, and became significantly higher in stage 4.
FGF-23 could be a good predictor of BAC in CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Basmah O.& Tawfiq, Jamal A.& Ahmad, Husayni M.& Umar, Hamdi H.. 2022. Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients. Suez Canal University Medical Journal،Vol. 25, no. 1, pp.80-91.
https://search.emarefa.net/detail/BIM-1333162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Basmah O.…[et al.]. Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients. Suez Canal University Medical Journal Vol. 25, no. 1 (2022), pp.80-91.
https://search.emarefa.net/detail/BIM-1333162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Basmah O.& Tawfiq, Jamal A.& Ahmad, Husayni M.& Umar, Hamdi H.. Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients. Suez Canal University Medical Journal. 2022. Vol. 25, no. 1, pp.80-91.
https://search.emarefa.net/detail/BIM-1333162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 90-91
رقم السجل
BIM-1333162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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