Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients
Joint Authors
Ibrahim, Basmah O.
Ahmad, Husayni M.
Umar, Hamdi H.
Tawfiq, Jamal A.
Source
Suez Canal University Medical Journal
Issue
Vol. 25, Issue 1 (31 Mar. 2022), pp.80-91, 12 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2022-03-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Background : vascular calcification (VC) plays a major role in cardiovascular disease (CVD), which is one of the main causes of mortality in patients with chronic kidney disease (CKD).
during the early stages of CKD, fibroblast growth factor-23 (FGF-23) levels increase to keep serum phosphorus within the normal range.
FGF23 may be associated with death and cardiovascular events in CKD patients.
aim : the study aimed at early detection of breast arterial calcification (BAC) and higher levels of FGF-23 as indicators of systemic VC in patients with different stages of CKD.
methodology : the patients were divided into 3 groups ; representing stages 2, 3 & 4 of CKD women, and the 4th group was considered as a control group.
the selected participants were subjected to history taking, mammogram to detect BAC and biochemical assessment of lipid profile, serum creatinine, Mg, P, Ca, PTH and FGF23.
Results : the presence of BAC in about 81.8% of stage 4 CKD patients compared with 50% in stage 3 CKD, also in the majority of stage 4 CKD patients had high FGF-23.
receiver operator characteristic (ROC) curve analysis showed serum FGF-23 as a potential predictor of BAC (AUC = 0.874) in CKD patients at the cut-off point of 77.5 ng / ml (sensitivity 78%, specificity 76%).
Conclusion : although it is difficult to determine the definite stage at which the risk of VC begins but, in our study, it began late in stage 2 CKD, gradually increased prevalence through stage 3, and became significantly higher in stage 4.
FGF-23 could be a good predictor of BAC in CKD.
American Psychological Association (APA)
Ibrahim, Basmah O.& Tawfiq, Jamal A.& Ahmad, Husayni M.& Umar, Hamdi H.. 2022. Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients. Suez Canal University Medical Journal،Vol. 25, no. 1, pp.80-91.
https://search.emarefa.net/detail/BIM-1333162
Modern Language Association (MLA)
Ibrahim, Basmah O.…[et al.]. Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients. Suez Canal University Medical Journal Vol. 25, no. 1 (2022), pp.80-91.
https://search.emarefa.net/detail/BIM-1333162
American Medical Association (AMA)
Ibrahim, Basmah O.& Tawfiq, Jamal A.& Ahmad, Husayni M.& Umar, Hamdi H.. Association of fibroblast growth factor-23 and early detection of breast arterial calcification in different stages of chronic kidney disease patients. Suez Canal University Medical Journal. 2022. Vol. 25, no. 1, pp.80-91.
https://search.emarefa.net/detail/BIM-1333162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 90-91
Record ID
BIM-1333162