Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95)‎ by E102 food dye administration in male mice : possible immune modulation by vitamin E

الملخص EN

-This could be considered first study that concerned with evaluation of the immunomodulatory effect of vitamin E (vit E) against renal cytokines alteration induced by synthetic food dyes in male mice.

Mice were divided into 4 groups; mice in group 1 were the control, animals in group 2 received vit E (100mg/kg bw), group 3 mice administered E102 (300mg/kg bw), and mice from group 4 received E102+vit E for 28 days.

Nephrotoxicity in mice was confirmed by assessing changes in levels of the renal markers and antioxidant status.

Co-administration of vit E resulted in restoration of altered levels of renal functions (electrolytes, creatinine & urea), antioxidants status and different cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95).

The therapeutic role of vit E against E102 food dye-induced nephrotoxicity could be attributed to their antioxidant effects and free radical scavenging properties.