Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E
Other Title(s)
تغيير السيتوكينات الكلوية (Bcl-2 ،caspase-3 ،Cox-2 ،TNF-α و (CD95عن طريق تعاطي صبغة الطعام E102 في ذكور الفئران : التأثير المناعي المحتمل لفيتامين ه
Joint Authors
al-Shaykh, Turki Mubarak Hamdan
al-Shirbini, Sali Abd al-Hakim
Ibrahim, Amal Atiyah al-Mursi
Source
Journal of the North for Basic and Applied Sciences
Issue
Vol. 6, Issue 2 (30 Nov. 2021), pp.89-100, 12 p.
Publisher
Northern Border University Scientific Publishing Center
Publication Date
2021-11-30
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Abstract EN
-This could be considered first study that concerned with evaluation of the immunomodulatory effect of vitamin E (vit E) against renal cytokines alteration induced by synthetic food dyes in male mice.
Mice were divided into 4 groups; mice in group 1 were the control, animals in group 2 received vit E (100mg/kg bw), group 3 mice administered E102 (300mg/kg bw), and mice from group 4 received E102+vit E for 28 days.
Nephrotoxicity in mice was confirmed by assessing changes in levels of the renal markers and antioxidant status.
Co-administration of vit E resulted in restoration of altered levels of renal functions (electrolytes, creatinine & urea), antioxidants status and different cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95).
The therapeutic role of vit E against E102 food dye-induced nephrotoxicity could be attributed to their antioxidant effects and free radical scavenging properties.
American Psychological Association (APA)
Ibrahim, Amal Atiyah al-Mursi& al-Shaykh, Turki Mubarak Hamdan& al-Shirbini, Sali Abd al-Hakim. 2021. Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E. Journal of the North for Basic and Applied Sciences،Vol. 6, no. 2, pp.89-100.
https://search.emarefa.net/detail/BIM-1340992
Modern Language Association (MLA)
Ibrahim, Amal Atiyah al-Mursi…[et al.]. Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E. Journal of the North for Basic and Applied Sciences Vol. 6, no. 2 (Nov. 2021), pp.89-100.
https://search.emarefa.net/detail/BIM-1340992
American Medical Association (AMA)
Ibrahim, Amal Atiyah al-Mursi& al-Shaykh, Turki Mubarak Hamdan& al-Shirbini, Sali Abd al-Hakim. Alteration of renal cytokines (TNF-α, Cox-2, caspase-3, Bcl-2, and CD95) by E102 food dye administration in male mice : possible immune modulation by vitamin E. Journal of the North for Basic and Applied Sciences. 2021. Vol. 6, no. 2, pp.89-100.
https://search.emarefa.net/detail/BIM-1340992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 98-100
Record ID
BIM-1340992