Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats
المؤلفون المشاركون
al-Sawi, Abd al-Salam F.
al-Maddawi, Zaynab Kh.
Ashura, Nivin R.
المصدر
Alexandria Journal of Veterinary Sciences
العدد
المجلد 59، العدد 2 (31 أكتوبر/تشرين الأول 2018)، ص ص. 125-135، 11ص.
الناشر
جامعة الإسكندرية كلية الطب البيطري
تاريخ النشر
2018-10-31
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The present study was conducted to evaluate the protective effect of Silymarin on deleterious effects of dexamethasone on hepatic and renal functions tests, hematological parameters and histopathological changes of some organs in male rats.
Twenty four mature male rats were used and divided equally into 4 groups .The first group was daily administered with distilled water (2ml/kg.
b.wt) orally by stomach tube and saline (2ml/kg.
b.wt) i/m twice weekly with 72 hrs interval .The second group was daily administered with silymarin ( 50mg/kg b.wt.), given orally by stomach tube.
The third group was treated with dexamethasone sodium phosphate (0.25mg/kg.
b.wt) intramuscularly twice weekly with 72 hrs interval .The fourth group was treated with dexamethasone sodium phosphate by the same dose concomitantly with daily administration of silymarin .The treatment was done for one month .The obtained results showed that i.m.
injection of dexamethasone induced a significant (P≤ 0.05) increase in serum levels of alanine amino transfers (ALT), alkaline phosphatase (ALP) ,triglycerides, malondaldahyde (MDA), urea and creatinine .While, it induced a significant (P≤ 0.05) decrease in serum total protein , globulin values, total cholesterol, total antioxidant capacity ,Red blood corpuscles count (RBCs ), white blood cell count (WBCs), packed cell volume (PCV%) , also, it induced eosinopenia, lymphocytopenia and neutrophilia .Moreover, dexamethasone induced histopathological changes on liver , kidney , spleen and lymph node .
While, administration of silymarin concomitantly with dexamethasone induced marked improvement in all previous biochemical and hematogical parameters induced by dexamethasone in male albino rats.
It could be concluded that dexamethasone induced hazard effects on blood picture, hepatic and renal function testes .While, silymarin could be successed to ameliorate these effects in male albino rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sawi, Abd al-Salam F.& al-Maddawi, Zaynab Kh.& Ashura, Nivin R.. 2018. Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats. Alexandria Journal of Veterinary Sciences،Vol. 59, no. 2, pp.125-135.
https://search.emarefa.net/detail/BIM-1341288
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sawi, Abd al-Salam F.…[et al.]. Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats. Alexandria Journal of Veterinary Sciences Vol. 59, no. 2 (Oct. 2018), pp.125-135.
https://search.emarefa.net/detail/BIM-1341288
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sawi, Abd al-Salam F.& al-Maddawi, Zaynab Kh.& Ashura, Nivin R.. Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats. Alexandria Journal of Veterinary Sciences. 2018. Vol. 59, no. 2, pp.125-135.
https://search.emarefa.net/detail/BIM-1341288
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 133-135
رقم السجل
BIM-1341288
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر