Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats
Joint Authors
al-Sawi, Abd al-Salam F.
al-Maddawi, Zaynab Kh.
Ashura, Nivin R.
Source
Alexandria Journal of Veterinary Sciences
Issue
Vol. 59, Issue 2 (31 Oct. 2018), pp.125-135, 11 p.
Publisher
Alexandria University Faculty of Veterinary Medicine
Publication Date
2018-10-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The present study was conducted to evaluate the protective effect of Silymarin on deleterious effects of dexamethasone on hepatic and renal functions tests, hematological parameters and histopathological changes of some organs in male rats.
Twenty four mature male rats were used and divided equally into 4 groups .The first group was daily administered with distilled water (2ml/kg.
b.wt) orally by stomach tube and saline (2ml/kg.
b.wt) i/m twice weekly with 72 hrs interval .The second group was daily administered with silymarin ( 50mg/kg b.wt.), given orally by stomach tube.
The third group was treated with dexamethasone sodium phosphate (0.25mg/kg.
b.wt) intramuscularly twice weekly with 72 hrs interval .The fourth group was treated with dexamethasone sodium phosphate by the same dose concomitantly with daily administration of silymarin .The treatment was done for one month .The obtained results showed that i.m.
injection of dexamethasone induced a significant (P≤ 0.05) increase in serum levels of alanine amino transfers (ALT), alkaline phosphatase (ALP) ,triglycerides, malondaldahyde (MDA), urea and creatinine .While, it induced a significant (P≤ 0.05) decrease in serum total protein , globulin values, total cholesterol, total antioxidant capacity ,Red blood corpuscles count (RBCs ), white blood cell count (WBCs), packed cell volume (PCV%) , also, it induced eosinopenia, lymphocytopenia and neutrophilia .Moreover, dexamethasone induced histopathological changes on liver , kidney , spleen and lymph node .
While, administration of silymarin concomitantly with dexamethasone induced marked improvement in all previous biochemical and hematogical parameters induced by dexamethasone in male albino rats.
It could be concluded that dexamethasone induced hazard effects on blood picture, hepatic and renal function testes .While, silymarin could be successed to ameliorate these effects in male albino rats.
American Psychological Association (APA)
al-Sawi, Abd al-Salam F.& al-Maddawi, Zaynab Kh.& Ashura, Nivin R.. 2018. Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats. Alexandria Journal of Veterinary Sciences،Vol. 59, no. 2, pp.125-135.
https://search.emarefa.net/detail/BIM-1341288
Modern Language Association (MLA)
al-Sawi, Abd al-Salam F.…[et al.]. Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats. Alexandria Journal of Veterinary Sciences Vol. 59, no. 2 (Oct. 2018), pp.125-135.
https://search.emarefa.net/detail/BIM-1341288
American Medical Association (AMA)
al-Sawi, Abd al-Salam F.& al-Maddawi, Zaynab Kh.& Ashura, Nivin R.. Role of silymarin in restoring the deleterious effects induced by dexamethasone in male rats. Alexandria Journal of Veterinary Sciences. 2018. Vol. 59, no. 2, pp.125-135.
https://search.emarefa.net/detail/BIM-1341288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 133-135
Record ID
BIM-1341288