Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?
المؤلفون المشاركون
al-Ghaithi, Ahmad
Husband, John
al-Maskari, Sultan
المصدر
Sultan Qaboos University Medical Journal
العدد
المجلد 21، العدد 2 (31 مايو/أيار 2021)، ص ص. 297-301، 5ص.
الناشر
جامعة السلطان قابوس كلية الطب و العلوم الصحية
تاريخ النشر
2021-05-31
دولة النشر
سلطنة عمان
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives : bone failure due to avascular necrosis (AVN) is a complex pathological phenomenon.
analysis of molecular changes in the bone matrix may help to shed light on the disease process and guide management.
this study aimed to explore changes in bone quality and structural damage caused by sickle cell disease (SCD)- induced AVN using Raman spectroscopy.
methods : a total of 10 necrotic femoral heads were obtained from seven SCD patients who underwent total hip replacements.
the femoral heads were cut in half and scanned using Raman spectroscopy in correlation with preoperative magnetic resonance imaging to identify necrotic and healthy control areas.
Subsequently, samples were examined to determine changes in bone mineralisation, crystallinity, carbonate content, collagen cross-linking and mineral and collagen fibril orientation.
results : Significant changes were observed in bone mineral content, mineral-to-organic content and collagen fibril orientation in necrotic compared to control areas (P ≤0.050).
conclusion : the necrotic samples displayed severe structural damage and loss of mineral and organic contents.
Similar Raman signals have been reported in other metabolic bone diseases such as osteoporosis, thereby potentially supporting the use of medical treatment in AVN to promote bone quality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ghaithi, Ahmad& Husband, John& al-Maskari, Sultan. 2021. Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?. Sultan Qaboos University Medical Journal،Vol. 21, no. 2, pp.297-301.
https://search.emarefa.net/detail/BIM-1344926
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ghaithi, Ahmad…[et al.]. Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?. Sultan Qaboos University Medical Journal Vol. 21, no. 2 (May. 2021), pp.297-301.
https://search.emarefa.net/detail/BIM-1344926
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ghaithi, Ahmad& Husband, John& al-Maskari, Sultan. Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?. Sultan Qaboos University Medical Journal. 2021. Vol. 21, no. 2, pp.297-301.
https://search.emarefa.net/detail/BIM-1344926
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 301
رقم السجل
BIM-1344926
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر