Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?
Joint Authors
al-Ghaithi, Ahmad
Husband, John
al-Maskari, Sultan
Source
Sultan Qaboos University Medical Journal
Issue
Vol. 21, Issue 2 (31 May. 2021), pp.297-301, 5 p.
Publisher
Sultan Qaboos University College of Medicine and Health Sciences
Publication Date
2021-05-31
Country of Publication
Oman
No. of Pages
5
Main Subjects
Abstract EN
Objectives : bone failure due to avascular necrosis (AVN) is a complex pathological phenomenon.
analysis of molecular changes in the bone matrix may help to shed light on the disease process and guide management.
this study aimed to explore changes in bone quality and structural damage caused by sickle cell disease (SCD)- induced AVN using Raman spectroscopy.
methods : a total of 10 necrotic femoral heads were obtained from seven SCD patients who underwent total hip replacements.
the femoral heads were cut in half and scanned using Raman spectroscopy in correlation with preoperative magnetic resonance imaging to identify necrotic and healthy control areas.
Subsequently, samples were examined to determine changes in bone mineralisation, crystallinity, carbonate content, collagen cross-linking and mineral and collagen fibril orientation.
results : Significant changes were observed in bone mineral content, mineral-to-organic content and collagen fibril orientation in necrotic compared to control areas (P ≤0.050).
conclusion : the necrotic samples displayed severe structural damage and loss of mineral and organic contents.
Similar Raman signals have been reported in other metabolic bone diseases such as osteoporosis, thereby potentially supporting the use of medical treatment in AVN to promote bone quality.
American Psychological Association (APA)
al-Ghaithi, Ahmad& Husband, John& al-Maskari, Sultan. 2021. Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?. Sultan Qaboos University Medical Journal،Vol. 21, no. 2, pp.297-301.
https://search.emarefa.net/detail/BIM-1344926
Modern Language Association (MLA)
al-Ghaithi, Ahmad…[et al.]. Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?. Sultan Qaboos University Medical Journal Vol. 21, no. 2 (May. 2021), pp.297-301.
https://search.emarefa.net/detail/BIM-1344926
American Medical Association (AMA)
al-Ghaithi, Ahmad& Husband, John& al-Maskari, Sultan. Analysis of bone microarchitectural changes and structural damage in sickle cell disease-induced avascular necrosis using Raman spectroscopy : is there potential for medical management?. Sultan Qaboos University Medical Journal. 2021. Vol. 21, no. 2, pp.297-301.
https://search.emarefa.net/detail/BIM-1344926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 301
Record ID
BIM-1344926