The association study between tumor necrosis factor-receptor 1 36 AG (TNFR1 36 AG) gene polymorphism and Azoospermic infertile men in Erbil city
المؤلف
المصدر
ZANCO Journal of Pure and Applied Sciences
العدد
المجلد 33، العدد 1 (28 فبراير/شباط 2021)، ص ص. 27-34، 8ص.
الناشر
جامعة صلاح الدين قسم النشر العلمي
تاريخ النشر
2021-02-28
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Tumor necrosis factor-alpha (TNF-α) is a multifunctional cytokine that controls cellular activities related to spermatogenesis.
(TNFR1) affects TNF- α activity and also may leads to gene dysfunction and male infertility.
This retrospective study was done to assess the linkage of TNFR1 36 A/G gene polymorphism with idiopathic azoospermia in Erbil City.
The present study was carried out on 98 infertile, 109 fertile males as healthy control.
TNFR1 36 A/G gene polymorphisms were detected in all study subjects, and their seminal fluids were analyzed.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method is used for identify polymorphism in both cases and control groups.
MspA1I restriction enzyme were digested PCR products.
Digested and PCR products were analyzed by 3% gel electrophoresis for 45 minutes at 97 V.
.
The results of the present study showed that the incidence of AG genotype in azoospermia male higher than control groups (OR=2.069(1.154-3.708), P=0.014, this study found that G allele frequency in azoospermia men had a significant difference compared to the control group (OR=1.487 (0.992-2.170).
Moreover, AG genotype and G allele associated with an increased risk of non-obstructive azoospermia in Erbil City.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Said, Ashti Muhammad Amin. 2021. The association study between tumor necrosis factor-receptor 1 36 AG (TNFR1 36 AG) gene polymorphism and Azoospermic infertile men in Erbil city. ZANCO Journal of Pure and Applied Sciences،Vol. 33, no. 1, pp.27-34.
https://search.emarefa.net/detail/BIM-1387364
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Said, Ashti Muhammad Amin. The association study between tumor necrosis factor-receptor 1 36 AG (TNFR1 36 AG) gene polymorphism and Azoospermic infertile men in Erbil city. ZANCO Journal of Pure and Applied Sciences Vol. 33, no. 1 (2021), pp.27-34.
https://search.emarefa.net/detail/BIM-1387364
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Said, Ashti Muhammad Amin. The association study between tumor necrosis factor-receptor 1 36 AG (TNFR1 36 AG) gene polymorphism and Azoospermic infertile men in Erbil city. ZANCO Journal of Pure and Applied Sciences. 2021. Vol. 33, no. 1, pp.27-34.
https://search.emarefa.net/detail/BIM-1387364
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 32-34
رقم السجل
BIM-1387364
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر