Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms

المؤلفون المشاركون

Fakhri, Nabil A.
Qadir, Hemn A.

المصدر

ZANCO Journal of Pure and Applied Sciences

الناشر

جامعة صلاح الدين قسم النشر العلمي

تاريخ النشر

2017-08-31

دولة النشر

العراق

عدد الصفحات

8

التخصصات الرئيسية

الكيمياء
علم الصيدلة

الملخص الإنجليزي

A rapid and simple spectrophotometric procedure for the estimation of promethazine HCl in pure and pharmaceutical dosage forms is reported with the aid of the oxidation of the drug.

The promethazine HCl is oxidized with chromium trioxide in acidic medium, which leads to form a product, existing maximum absorption at 515 nm.

Many parameters of the reaction conditions have been studied and optimized to enhance the sensitivity of the proposed method.

After plotting the calibration graph, it was found that Beer’s law is obeyed over the concentration range of 5.0 – 100.0 μg/mL, with 3.0 μg/mL and 5.2×103 l/mol.

cm.

of detection limit and molar absorptivity, respectively.

The accuracy and precision of the method were tested and obtained values were acceptable.

The influence of common interferences on the proposed method was studied and the method was applied for the estimation of promethazine HCl in different pharmaceutical formulations available in market with good recoveries.

نوع البيانات

أوراق مؤتمرات

رقم السجل

BIM-1388910

• APA
• MLA
• AMA