Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms

Joint Authors

Fakhri, Nabil A.
Qadir, Hemn A.

Source

ZANCO Journal of Pure and Applied Sciences

Publisher

Salahaddin University-Erbil Department of Scientific Publications

Publication Date

2017-08-31

Country of Publication

Iraq

No. of Pages

8

Main Subjects

Chemistry
Pharmacology

English Abstract

A rapid and simple spectrophotometric procedure for the estimation of promethazine HCl in pure and pharmaceutical dosage forms is reported with the aid of the oxidation of the drug.

The promethazine HCl is oxidized with chromium trioxide in acidic medium, which leads to form a product, existing maximum absorption at 515 nm.

Many parameters of the reaction conditions have been studied and optimized to enhance the sensitivity of the proposed method.

After plotting the calibration graph, it was found that Beer’s law is obeyed over the concentration range of 5.0 – 100.0 μg/mL, with 3.0 μg/mL and 5.2×103 l/mol.

cm.

of detection limit and molar absorptivity, respectively.

The accuracy and precision of the method were tested and obtained values were acceptable.

The influence of common interferences on the proposed method was studied and the method was applied for the estimation of promethazine HCl in different pharmaceutical formulations available in market with good recoveries.

Data Type

Conference Papers

Record ID

BIM-1388910

American Psychological Association (APA)

Qadir, Hemn A.& Fakhri, Nabil A.. 2017-08-31. Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms. International Conference and Workshop on Basic and Applied Sciences (6th : 2017 : Salahaddin University-Erbil, Iraq). . Vol. 29, no. 4 (Supplement) (2017), pp.107-114.Irbil Iraq : Salahaddin University-Erbil Department of Scientific Publications.
https://search.emarefa.net/detail/BIM-1388910

Modern Language Association (MLA)

Qadir, Hemn A.& Fakhri, Nabil A.. Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms. . Irbil Iraq : Salahaddin University-Erbil Department of Scientific Publications. 2017-08-31.
https://search.emarefa.net/detail/BIM-1388910

American Medical Association (AMA)

Qadir, Hemn A.& Fakhri, Nabil A.. Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms. . International Conference and Workshop on Basic and Applied Sciences (6th : 2017 : Salahaddin University-Erbil, Iraq).
https://search.emarefa.net/detail/BIM-1388910