Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms
Joint Authors
Fakhri, Nabil A.
Qadir, Hemn A.
Source
ZANCO Journal of Pure and Applied Sciences
Publisher
Salahaddin University-Erbil Department of Scientific Publications
Publication Date
2017-08-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
English Abstract
A rapid and simple spectrophotometric procedure for the estimation of promethazine HCl in pure and pharmaceutical dosage forms is reported with the aid of the oxidation of the drug.
The promethazine HCl is oxidized with chromium trioxide in acidic medium, which leads to form a product, existing maximum absorption at 515 nm.
Many parameters of the reaction conditions have been studied and optimized to enhance the sensitivity of the proposed method.
After plotting the calibration graph, it was found that Beer’s law is obeyed over the concentration range of 5.0 – 100.0 μg/mL, with 3.0 μg/mL and 5.2×103 l/mol.
cm.
of detection limit and molar absorptivity, respectively.
The accuracy and precision of the method were tested and obtained values were acceptable.
The influence of common interferences on the proposed method was studied and the method was applied for the estimation of promethazine HCl in different pharmaceutical formulations available in market with good recoveries.
Data Type
Conference Papers
Record ID
BIM-1388910
American Psychological Association (APA)
Qadir, Hemn A.& Fakhri, Nabil A.. 2017-08-31. Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms. International Conference and Workshop on Basic and Applied Sciences (6th : 2017 : Salahaddin University-Erbil, Iraq). . Vol. 29, no. 4 (Supplement) (2017), pp.107-114.Irbil Iraq : Salahaddin University-Erbil Department of Scientific Publications.
https://search.emarefa.net/detail/BIM-1388910
Modern Language Association (MLA)
Qadir, Hemn A.& Fakhri, Nabil A.. Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms. . Irbil Iraq : Salahaddin University-Erbil Department of Scientific Publications. 2017-08-31.
https://search.emarefa.net/detail/BIM-1388910
American Medical Association (AMA)
Qadir, Hemn A.& Fakhri, Nabil A.. Spectrophotometric determination of promethazine hydrochloride in pure and pharmaceutical dosage forms. . International Conference and Workshop on Basic and Applied Sciences (6th : 2017 : Salahaddin University-Erbil, Iraq).
https://search.emarefa.net/detail/BIM-1388910