Protective effect of worm-wood (artemisia absinthium l.)‎ and lion’s foot (alchemilla vulgaris l.)‎ against l-arginine- induced chronic renal failure in rats and their fortified to hamburgers

الملخص EN

Background: the prevalence of chronic kidney disease (CKD) has dramatically increased in the past two decades and has become a significant public health problem globally.

the present work aimed to highlight the protective effect of dried lion’s foot (alChemilla vulgaris) and wormwood (artemisia absinthium) and their mixture against l-arginine- induced chronic renal failure.

also, the preparation of hamburgers that are fortified with lion’s foot and worm-wood powders as an available product rich in bioactive components to help kidney patients.

material and methods: fortyeight rats were divided into 8 groups (6 rats each) as follow: negative control (g1): fed on the basal diet, positive control (g2): a fed basal diet containing 2% l-arginine to induce chronic renal failure, g (3 and 4): same positive control + 5% of a.

vulgaris and a.

absinthium, respectively, g (5 and 6): same positive control + 10% of a.

vulgaris and a.

absinthium respectively, g (7 and 8): same positive control + mixture of (a.

vulgaris and a.

absinthium) at 5 and 10%, respectively.

results: showed that administration of a.

vulgaris and a.

absinthium and their mixture at all dosages significantly improved, rats’ body weight gain percentage, feed intake, reduced the elevated serum levels of liver functions (alt, ast, alp, albumin and total bilirubin), and kidney functions (creatinine, urea and uric acid), potassium, while serum sodium levels increased compared to l-arginine group.

these were associated with a significant increment of serum total antioxidant, sod, GSH-RX and cat meanwhile, a significant decrement of mda oxidative stress biomarker was achieved.

the histopathologic evaluation suggested that a.

vulgaris and a.

absinthium and their mixture decreased hepatic and renal necrosis induced by l arginine.

the panelists accepted hamburgers up to 5% lion’s foot and only 2.5% for wormwood.

conclusion: it could be concluded that a.

vulgaris and a.

absinthium showed promising renal and hepatoprotective activities against adversely l-arginine and these effects may be due to their antioxidant contents, providing scientific support for use of these plants in the treatment of kidney and liver disorders.