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Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway
المؤلفون المشاركون
Song, Qin
Wang, Yuanxin
Yang, Haiyan
Li, Bingshu
Pan, Jiming
Zhang, Yan
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 6 (30 يونيو/حزيران 2021)، ص ص. 3193-3197، 5ص.
الناشر
تاريخ النشر
2021-06-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
The main aim of this study was to evaluate the neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke model rats and its effect on extracellular regulated protein kinase 1/2 (REK1/2) signaling pathway, and to clarify the possible mechanism of aspirin combined with ginkgolide injection on neuroprotective mechanism.
Experimental rats were randomly divided into sham group, model group, aspirin group, ginkgolide group and combination group (aspirin + ginkgolide injection) (n = 20).
The results revealed scores of neurological dysfunction and infarct volume in aspirin group, ginkgolide group and combination group rats were lower than those in model group (P < 0.05).
Score of neurological dysfunction and the volume of cerebral infarction in combination group rats were lower than those in aspirin group and ginkgolide group (P < 0.05).
Combination of aspirin and ginkgolide injection could better reduce brain water content, reduce apoptosis rate of cortical cells P < 0.05, reduce expression levels of caspase-3, Bax and p-REK1/2 proteins in ischemic brain tissue P < 0.05, and increase expression level of Bcl-2 protein than aspirin and ginkgolide injection alone P < 0.05).
In conclusion, the synergistic neuroprotective effect of aspirin and ginkgolide injection on cerebral ischemic stroke rats is better than that of aspirin and ginkgolide injection alone.
The mechanism of action may be that the two compounds can play a synergistic role and inhibit the activation of REK1/2 signaling pathway, thus inhibiting apoptosis of nerve cells and exerting neuroprotective effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Yan& Song, Qin& Wang, Yuanxin& Li, Bingshu& Pan, Jiming& Yang, Haiyan. 2021. Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3193-3197.
https://search.emarefa.net/detail/BIM-1407766
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Yan…[et al.]. Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3193-3197.
https://search.emarefa.net/detail/BIM-1407766
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Yan& Song, Qin& Wang, Yuanxin& Li, Bingshu& Pan, Jiming& Yang, Haiyan. Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3193-3197.
https://search.emarefa.net/detail/BIM-1407766
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3197
رقم السجل
BIM-1407766
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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