Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway
Joint Authors
Song, Qin
Wang, Yuanxin
Yang, Haiyan
Li, Bingshu
Pan, Jiming
Zhang, Yan
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 6 (30 Jun. 2021), pp.3193-3197, 5 p.
Publisher
Publication Date
2021-06-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
The main aim of this study was to evaluate the neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke model rats and its effect on extracellular regulated protein kinase 1/2 (REK1/2) signaling pathway, and to clarify the possible mechanism of aspirin combined with ginkgolide injection on neuroprotective mechanism.
Experimental rats were randomly divided into sham group, model group, aspirin group, ginkgolide group and combination group (aspirin + ginkgolide injection) (n = 20).
The results revealed scores of neurological dysfunction and infarct volume in aspirin group, ginkgolide group and combination group rats were lower than those in model group (P < 0.05).
Score of neurological dysfunction and the volume of cerebral infarction in combination group rats were lower than those in aspirin group and ginkgolide group (P < 0.05).
Combination of aspirin and ginkgolide injection could better reduce brain water content, reduce apoptosis rate of cortical cells P < 0.05, reduce expression levels of caspase-3, Bax and p-REK1/2 proteins in ischemic brain tissue P < 0.05, and increase expression level of Bcl-2 protein than aspirin and ginkgolide injection alone P < 0.05).
In conclusion, the synergistic neuroprotective effect of aspirin and ginkgolide injection on cerebral ischemic stroke rats is better than that of aspirin and ginkgolide injection alone.
The mechanism of action may be that the two compounds can play a synergistic role and inhibit the activation of REK1/2 signaling pathway, thus inhibiting apoptosis of nerve cells and exerting neuroprotective effect.
American Psychological Association (APA)
Zhang, Yan& Song, Qin& Wang, Yuanxin& Li, Bingshu& Pan, Jiming& Yang, Haiyan. 2021. Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3193-3197.
https://search.emarefa.net/detail/BIM-1407766
Modern Language Association (MLA)
Zhang, Yan…[et al.]. Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3193-3197.
https://search.emarefa.net/detail/BIM-1407766
American Medical Association (AMA)
Zhang, Yan& Song, Qin& Wang, Yuanxin& Li, Bingshu& Pan, Jiming& Yang, Haiyan. Neuroprotective effect of aspirin combined with ginkgolide injection on cerebral ischemic stroke rats and its effect on ERK12 signal pathway. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3193-3197.
https://search.emarefa.net/detail/BIM-1407766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3197
Record ID
BIM-1407766