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Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TORPI3KAKT signalling pathway
المؤلفون المشاركون
Liu, Bingqian
Kuang, Weiwei
Shao, Yinhong
Ren, Hong
Zhu, Wenlong
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 5 (31 مايو/أيار 2021)، ص ص. 2739-2746، 8ص.
الناشر
تاريخ النشر
2021-05-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The current study was undertaken to investigate anticancer activity of coumestrol phytoestrogen against human skin cancer.
MTT assay was performed for cell viability assessment and clonogenic assay for cell colony formation assessment.
Apoptosis was analysed by Annexin V/FITC staining, AO/EB staining and western blotting assays.
Effects on the m-TOR/PI3K/AKT signalling pathway were investigated by western blotting.
Results indicated that coumestrol induced significant toxicity in human skin cancer cells in con-trast to mouse skin cancer cells.
The proliferation rate in normal skin cells remained almost intact.
Annexin V-FITC and AO/EB staining assays indicated coumestrol induced cytotoxicity in skin cancer cells is mediated through apoptosis stimulation.
The apoptosis in skin cancer cells was mediated through caspase-activation.
Cell migration and invasion was inhibited by coumestrol in human skin cancer cells via inhibition of MMP-2 and MMP-9 expressions.
Moreover, m-TOR/PI3K/AKT signalling pathway in SKEM-5 cells was blocked by coumestrol.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuang, Weiwei& Zhu, Wenlong& Ren, Hong& Shao, Yinhong& Liu, Bingqian. 2021. Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TORPI3KAKT signalling pathway. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.2739-2746.
https://search.emarefa.net/detail/BIM-1414502
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuang, Weiwei…[et al.]. Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TORPI3KAKT signalling pathway. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.2739-2746.
https://search.emarefa.net/detail/BIM-1414502
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuang, Weiwei& Zhu, Wenlong& Ren, Hong& Shao, Yinhong& Liu, Bingqian. Plant derived coumestrol phytochemical targets human skin carcinoma cells by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and invasion and modulation of m-TORPI3KAKT signalling pathway. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.2739-2746.
https://search.emarefa.net/detail/BIM-1414502
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 2745-2746
رقم السجل
BIM-1414502
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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