Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models
المؤلفون المشاركون
Yasiri, Mahdi
Azami, Golnaz
Muzaffari, Ali Ashraf
Mansournia, Muhammad Ali
Ghiasi, Baharah
Sayehmiri, Kourosh
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 22، العدد 7 (31 يوليو/تموز 2020)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2020-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background: Lipid disorders are a well-documented risk factor for chronic kidney disease (CKD), but the impact of lipid abnormalities in the progression of the disease remains mixed.
Objectives: The current study aimed to extend the existing knowledge about the effect of lipid disorders in disease progression from moderate to the severe stage using Flexible parametric survival models.
Methods: This retrospective cohort study included 308 moderate CKD patients who received the nephrologist follow-up visits at the nephrology clinic, Ilam (Iran), from 2012 to 2019.
The survival time was determined based on the time medically diagnosed with moderate stages (GFR = 59-55 mL/min per 1.73 m 2) to the time of progression to the severe stage (GFR = 29-25 mL/min per 1.73 m 2) hazard using flexible parametric survival models.
Results: In univariate analysis, high levels of TG, LDL, and cholesterol were important risk factors which affect the CKD progression.
The hazard of patients with TG > 200 mg/dL was 1.69 times higher than patients with desirable TG levels (P = 0.09).
Moreover, for patients with LDL > 160 mg/dL, the hazard was 2.12 times higher than patients with desirable LDL levels (P = 0.01).
The hazard of patients with total cholesterol levels > 240 mg/dL was 2.10 times higher than patients with desirable cholesterol levels (P = 0.003).
The adjusted model was shown to better fit the PH model.
Cholesterol levels > 240 mg/dL remains a significant risk factor for CKD progression (P = 0.03).
Conclusions: Effective treatment programs should pay closer attention to screening and treatment of hyperlipidemia in patients diagnosed with moderate CKD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muzaffari, Ali Ashraf& Mansournia, Muhammad Ali& Sayehmiri, Kourosh& Ghiasi, Baharah& Yasiri, Mahdi& Azami, Golnaz. 2020. Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models. Iranian Red Crescent Medical Journal،Vol. 22, no. 7, pp.1-9.
https://search.emarefa.net/detail/BIM-1430498
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muzaffari, Ali Ashraf…[et al.]. Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models. Iranian Red Crescent Medical Journal Vol. 22, no. 7 (Jul. 2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1430498
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muzaffari, Ali Ashraf& Mansournia, Muhammad Ali& Sayehmiri, Kourosh& Ghiasi, Baharah& Yasiri, Mahdi& Azami, Golnaz. Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 7, pp.1-9.
https://search.emarefa.net/detail/BIM-1430498
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 8-9
رقم السجل
BIM-1430498
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر