Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models
Joint Authors
Yasiri, Mahdi
Azami, Golnaz
Muzaffari, Ali Ashraf
Mansournia, Muhammad Ali
Ghiasi, Baharah
Sayehmiri, Kourosh
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 7 (31 Jul. 2020), pp.1-9, 9 p.
Publisher
Publication Date
2020-07-31
Country of Publication
United Arab Emirates
No. of Pages
9
Main Subjects
Abstract EN
Background: Lipid disorders are a well-documented risk factor for chronic kidney disease (CKD), but the impact of lipid abnormalities in the progression of the disease remains mixed.
Objectives: The current study aimed to extend the existing knowledge about the effect of lipid disorders in disease progression from moderate to the severe stage using Flexible parametric survival models.
Methods: This retrospective cohort study included 308 moderate CKD patients who received the nephrologist follow-up visits at the nephrology clinic, Ilam (Iran), from 2012 to 2019.
The survival time was determined based on the time medically diagnosed with moderate stages (GFR = 59-55 mL/min per 1.73 m 2) to the time of progression to the severe stage (GFR = 29-25 mL/min per 1.73 m 2) hazard using flexible parametric survival models.
Results: In univariate analysis, high levels of TG, LDL, and cholesterol were important risk factors which affect the CKD progression.
The hazard of patients with TG > 200 mg/dL was 1.69 times higher than patients with desirable TG levels (P = 0.09).
Moreover, for patients with LDL > 160 mg/dL, the hazard was 2.12 times higher than patients with desirable LDL levels (P = 0.01).
The hazard of patients with total cholesterol levels > 240 mg/dL was 2.10 times higher than patients with desirable cholesterol levels (P = 0.003).
The adjusted model was shown to better fit the PH model.
Cholesterol levels > 240 mg/dL remains a significant risk factor for CKD progression (P = 0.03).
Conclusions: Effective treatment programs should pay closer attention to screening and treatment of hyperlipidemia in patients diagnosed with moderate CKD.
American Psychological Association (APA)
Muzaffari, Ali Ashraf& Mansournia, Muhammad Ali& Sayehmiri, Kourosh& Ghiasi, Baharah& Yasiri, Mahdi& Azami, Golnaz. 2020. Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models. Iranian Red Crescent Medical Journal،Vol. 22, no. 7, pp.1-9.
https://search.emarefa.net/detail/BIM-1430498
Modern Language Association (MLA)
Muzaffari, Ali Ashraf…[et al.]. Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models. Iranian Red Crescent Medical Journal Vol. 22, no. 7 (Jul. 2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1430498
American Medical Association (AMA)
Muzaffari, Ali Ashraf& Mansournia, Muhammad Ali& Sayehmiri, Kourosh& Ghiasi, Baharah& Yasiri, Mahdi& Azami, Golnaz. Effect of lipid abnormality on CKD progression from moderate to severe stage : application of flexible parametric proportional-hazards and proportional-odds models. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 7, pp.1-9.
https://search.emarefa.net/detail/BIM-1430498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 8-9
Record ID
BIM-1430498