Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria
العناوين الأخرى
تحديد المستوى التفريقي من دنا فيروس التهاب الكبد البائي بين حالتي التهاب الكبد البائي المزمن مع سلبية HBeAg و حمل الفيروس غير الفعال في سورية
المصدر
Journal of the Arab Board of Health Specializations
العدد
المجلد 6، العدد 3 (31 أغسطس/آب 2004)، ص ص. 231-238، 8ص.
الناشر
المجلس العربي للاختصاصات الصحية
تاريخ النشر
2004-08-31
دولة النشر
سوريا
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background & Objection: The level of hepatitis B virus DNA correlates with histological liver damage in HBeAg- negative chronic HBV infection.
The aim of the study was to compare the single serum HBV DNA levels, when present, between two different states ofHBeAg-negative chronic HBV infection (disease and inactive carrier state) and in addition with the HBeAg-positive chronic HBV infection state.
Methods: Of 83 patients with chronic HBV infection (HBsAg-positive chronic carriers), 39 were inactive HBV carriers (HBeAg-negative, with normal ALT levels).
Another 34 patients had HBeAg-negative chronic hepatitis B (CHB).
These either had elevated ALT levels or a history of elevation twice or more during the previous year.
Finally there were 10 patients with HBeAg-positive chronic HBV infection.
Quantification was done using PCR- based assay.
Results: The differences in HBV DNA levels between the group of inactive HBV carriers (median 9,1 *lif copies/ml) on the one side and the patients with HBeAg-negative chronic disease (median 3,6*10* copies/ml) and with HBeAg-positive chronic HBV infection (median 7,3 copies/ml) on the other side were statistically significant (in both cases P=0.000).
The use of HBV DNA levels of 30 000 copies/ml as a cut-off to separate inactive HBV carriers from patients with HBeAg-negative CHB succeeded in classifying all cases, as 39/39 were below this level.
At the same time, 62% (21/34) of patients with HBeAg-negative CHB had levels higher than this cutoff.
Overall, it correctly classified 82% (60/73) of all HBeAg-negative patients.
Use of HBV DNA level of 20000 copies/ml as a cut-off classified 97% (38/39) of inactive HBV carriers below it, and 74% (25/34) of patients with HBeAg-negative CHB above it, or correctly classified 86% (63/73) of all HBeAg-negative patients.
Conclusions: Determination of HBV DNA level with PCR-based assay is a powerful tool to differentiate between patients with HBeAg-negative chronic HBV infection with or without disease.
A cut-off DNA level of 30 000 copies/ml separated all inactive carriers.
The use of a cut-off DNA level of 20 000 copies/ml correctly classified 86% of all HBeAg-negative patients in this study
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Molchanova, Tatiana O.. 2004. Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria. Journal of the Arab Board of Health Specializations،Vol. 6, no. 3, pp.231-238.
https://search.emarefa.net/detail/BIM-143940
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Molchanova, Tatiana O.. Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria. Journal of the Arab Board of Health Specializations Vol. 6, no. 3(ِAugust 2004), pp.231-238.
https://search.emarefa.net/detail/BIM-143940
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Molchanova, Tatiana O.. Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria. Journal of the Arab Board of Health Specializations. 2004. Vol. 6, no. 3, pp.231-238.
https://search.emarefa.net/detail/BIM-143940
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
17
رقم السجل
BIM-143940
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر