Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria
Other Title(s)
تحديد المستوى التفريقي من دنا فيروس التهاب الكبد البائي بين حالتي التهاب الكبد البائي المزمن مع سلبية HBeAg و حمل الفيروس غير الفعال في سورية
Source
Journal of the Arab Board of Health Specializations
Issue
Vol. 6, Issue 3 (31 Aug. 2004), pp.231-238, 8 p.
Publisher
The Arab Board of Health Specializations
Publication Date
2004-08-31
Country of Publication
Syria
No. of Pages
8
Main Subjects
Abstract EN
Background & Objection: The level of hepatitis B virus DNA correlates with histological liver damage in HBeAg- negative chronic HBV infection.
The aim of the study was to compare the single serum HBV DNA levels, when present, between two different states ofHBeAg-negative chronic HBV infection (disease and inactive carrier state) and in addition with the HBeAg-positive chronic HBV infection state.
Methods: Of 83 patients with chronic HBV infection (HBsAg-positive chronic carriers), 39 were inactive HBV carriers (HBeAg-negative, with normal ALT levels).
Another 34 patients had HBeAg-negative chronic hepatitis B (CHB).
These either had elevated ALT levels or a history of elevation twice or more during the previous year.
Finally there were 10 patients with HBeAg-positive chronic HBV infection.
Quantification was done using PCR- based assay.
Results: The differences in HBV DNA levels between the group of inactive HBV carriers (median 9,1 *lif copies/ml) on the one side and the patients with HBeAg-negative chronic disease (median 3,6*10* copies/ml) and with HBeAg-positive chronic HBV infection (median 7,3 copies/ml) on the other side were statistically significant (in both cases P=0.000).
The use of HBV DNA levels of 30 000 copies/ml as a cut-off to separate inactive HBV carriers from patients with HBeAg-negative CHB succeeded in classifying all cases, as 39/39 were below this level.
At the same time, 62% (21/34) of patients with HBeAg-negative CHB had levels higher than this cutoff.
Overall, it correctly classified 82% (60/73) of all HBeAg-negative patients.
Use of HBV DNA level of 20000 copies/ml as a cut-off classified 97% (38/39) of inactive HBV carriers below it, and 74% (25/34) of patients with HBeAg-negative CHB above it, or correctly classified 86% (63/73) of all HBeAg-negative patients.
Conclusions: Determination of HBV DNA level with PCR-based assay is a powerful tool to differentiate between patients with HBeAg-negative chronic HBV infection with or without disease.
A cut-off DNA level of 30 000 copies/ml separated all inactive carriers.
The use of a cut-off DNA level of 20 000 copies/ml correctly classified 86% of all HBeAg-negative patients in this study
American Psychological Association (APA)
Molchanova, Tatiana O.. 2004. Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria. Journal of the Arab Board of Health Specializations،Vol. 6, no. 3, pp.231-238.
https://search.emarefa.net/detail/BIM-143940
Modern Language Association (MLA)
Molchanova, Tatiana O.. Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria. Journal of the Arab Board of Health Specializations Vol. 6, no. 3(ِAugust 2004), pp.231-238.
https://search.emarefa.net/detail/BIM-143940
American Medical Association (AMA)
Molchanova, Tatiana O.. Definition of cut-off hbv dna level between hbeag-negative chronic hepatitis b and inactive hbv carrier state in syria. Journal of the Arab Board of Health Specializations. 2004. Vol. 6, no. 3, pp.231-238.
https://search.emarefa.net/detail/BIM-143940
Data Type
Journal Articles
Language
English
Notes
17
Record ID
BIM-143940