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Expression of cyclin D1 in oral squamous cell carcinoma
المؤلفون المشاركون
Sulayman, Ahmad M.
Ahmad, Malak Abd al-Rahman Sayyid
Umar, Nazik
al-Laythi, Muna
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 16، العدد 4 (31 ديسمبر/كانون الأول 2021)، ص ص. 558-566، 9ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2021-12-31
دولة النشر
السودان
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background: Cyclin D1 expression regulates normal cell cycle.
Its deregulation or overexpression may cause disruption in the normal cell cycle control and lead to cancer progression.
In this study, we aimed to study the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and find its association with the different grades of oral tumors, if any.
Methods: This cross-sectional study included 40 formalin-fixed paraffin-embedded tissue blocks specimens of OSCC with variable grades.
The expression of cyclin D1 was evaluated through immunohistochemical (IHC) staining.
Results: A total of 40 (9 female and 31 male) samples were included, with a maleto-female ratio of 3.4:1.
The age ranged between 25 and 90 years with an average age of 65.5 years.
Twenty-five (62.5%) samples were diagnosed as well-differentiated squamous cell carcinoma (WDSCC) and fifteen (37.5%) as poorly differentiated squamous cell carcinoma (PDSCC).
No cases of moderately differentiated squamous carcinoma were included in the study.
The expression of cyclin D1 was detected in the cases of WDSCC and a lesser expression was seen in the PDSCC with a P-value of 0.0003, OR 1581 and 95% CI (29.8239 to 83810.7113).
Conclusion: Cyclin D1 is expressed in OSCC and stronger expression was detected in WDSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Malak Abd al-Rahman Sayyid& Umar, Nazik& Sulayman, Ahmad M.& al-Laythi, Muna. 2021. Expression of cyclin D1 in oral squamous cell carcinoma. Sudan Journal of Medical Sciences،Vol. 16, no. 4, pp.558-566.
https://search.emarefa.net/detail/BIM-1439660
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Malak Abd al-Rahman Sayyid…[et al.]. Expression of cyclin D1 in oral squamous cell carcinoma. Sudan Journal of Medical Sciences Vol. 16, no. 4 (2021), pp.558-566.
https://search.emarefa.net/detail/BIM-1439660
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Malak Abd al-Rahman Sayyid& Umar, Nazik& Sulayman, Ahmad M.& al-Laythi, Muna. Expression of cyclin D1 in oral squamous cell carcinoma. Sudan Journal of Medical Sciences. 2021. Vol. 16, no. 4, pp.558-566.
https://search.emarefa.net/detail/BIM-1439660
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 562-566
رقم السجل
BIM-1439660
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