Expression of cyclin D1 in oral squamous cell carcinoma
Joint Authors
Sulayman, Ahmad M.
Ahmad, Malak Abd al-Rahman Sayyid
Umar, Nazik
al-Laythi, Muna
Source
Sudan Journal of Medical Sciences
Issue
Vol. 16, Issue 4 (31 Dec. 2021), pp.558-566, 9 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2021-12-31
Country of Publication
Sudan
No. of Pages
9
Main Subjects
Abstract EN
Background: Cyclin D1 expression regulates normal cell cycle.
Its deregulation or overexpression may cause disruption in the normal cell cycle control and lead to cancer progression.
In this study, we aimed to study the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and find its association with the different grades of oral tumors, if any.
Methods: This cross-sectional study included 40 formalin-fixed paraffin-embedded tissue blocks specimens of OSCC with variable grades.
The expression of cyclin D1 was evaluated through immunohistochemical (IHC) staining.
Results: A total of 40 (9 female and 31 male) samples were included, with a maleto-female ratio of 3.4:1.
The age ranged between 25 and 90 years with an average age of 65.5 years.
Twenty-five (62.5%) samples were diagnosed as well-differentiated squamous cell carcinoma (WDSCC) and fifteen (37.5%) as poorly differentiated squamous cell carcinoma (PDSCC).
No cases of moderately differentiated squamous carcinoma were included in the study.
The expression of cyclin D1 was detected in the cases of WDSCC and a lesser expression was seen in the PDSCC with a P-value of 0.0003, OR 1581 and 95% CI (29.8239 to 83810.7113).
Conclusion: Cyclin D1 is expressed in OSCC and stronger expression was detected in WDSCC.
American Psychological Association (APA)
Ahmad, Malak Abd al-Rahman Sayyid& Umar, Nazik& Sulayman, Ahmad M.& al-Laythi, Muna. 2021. Expression of cyclin D1 in oral squamous cell carcinoma. Sudan Journal of Medical Sciences،Vol. 16, no. 4, pp.558-566.
https://search.emarefa.net/detail/BIM-1439660
Modern Language Association (MLA)
Ahmad, Malak Abd al-Rahman Sayyid…[et al.]. Expression of cyclin D1 in oral squamous cell carcinoma. Sudan Journal of Medical Sciences Vol. 16, no. 4 (2021), pp.558-566.
https://search.emarefa.net/detail/BIM-1439660
American Medical Association (AMA)
Ahmad, Malak Abd al-Rahman Sayyid& Umar, Nazik& Sulayman, Ahmad M.& al-Laythi, Muna. Expression of cyclin D1 in oral squamous cell carcinoma. Sudan Journal of Medical Sciences. 2021. Vol. 16, no. 4, pp.558-566.
https://search.emarefa.net/detail/BIM-1439660
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 562-566
Record ID
BIM-1439660