Selective modification of oleuropein, a multifunctional bioactive natural product

المؤلفون المشاركون

Kammoun, Majed
Jerbi, Amal
Mosset, Paul
Gree, Rene

المصدر

Journal of Saudi Chemical Society

العدد

المجلد 23، العدد 8 (31 ديسمبر/كانون الأول 2019)، ص ص. 1049-1059، 11ص.

الناشر

الجمعية الكيميائية السعودية

تاريخ النشر

2019-12-31

دولة النشر

السعودية

عدد الصفحات

11

التخصصات الرئيسية

الأحياء

الملخص EN

oleuropein is the major phenolic compound extracted from olive leaves and it is also pre sent in olive fruits and virgin olive oil.

It has already demonstrated a wide range of pharmacological activities, but new derivatives have to be designed in order to obtain useful Structure–Activity Relationships for this family of products, as well as new analogs with improved and/or different biological properties.

However, taking into account the multiple OH groups (catechol and sugar) present in oleuropein, the selective modification of this natural product is a challenging problem.

In this paper, we present an efficient strategy allowing the selective modification at the primary alcohol position of this natural product.

Using appropriate protection/deprotection sequences, we prepared by hemi synthesis several triazoles linked to the oleuropein core, as representative examples for the development of such an approach.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jerbi, Amal& Mosset, Paul& Gree, Rene& Kammoun, Majed. 2019. Selective modification of oleuropein, a multifunctional bioactive natural product. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1049-1059.
https://search.emarefa.net/detail/BIM-1443203

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jerbi, Amal…[et al.]. Selective modification of oleuropein, a multifunctional bioactive natural product. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1049-1059.
https://search.emarefa.net/detail/BIM-1443203

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jerbi, Amal& Mosset, Paul& Gree, Rene& Kammoun, Majed. Selective modification of oleuropein, a multifunctional bioactive natural product. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1049-1059.
https://search.emarefa.net/detail/BIM-1443203

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1057-1059

رقم السجل

BIM-1443203