Selective modification of oleuropein, a multifunctional bioactive natural product
Joint Authors
Kammoun, Majed
Jerbi, Amal
Mosset, Paul
Gree, Rene
Source
Journal of Saudi Chemical Society
Issue
Vol. 23, Issue 8 (31 Dec. 2019), pp.1049-1059, 11 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
11
Main Subjects
Abstract EN
oleuropein is the major phenolic compound extracted from olive leaves and it is also pre sent in olive fruits and virgin olive oil.
It has already demonstrated a wide range of pharmacological activities, but new derivatives have to be designed in order to obtain useful Structure–Activity Relationships for this family of products, as well as new analogs with improved and/or different biological properties.
However, taking into account the multiple OH groups (catechol and sugar) present in oleuropein, the selective modification of this natural product is a challenging problem.
In this paper, we present an efficient strategy allowing the selective modification at the primary alcohol position of this natural product.
Using appropriate protection/deprotection sequences, we prepared by hemi synthesis several triazoles linked to the oleuropein core, as representative examples for the development of such an approach.
American Psychological Association (APA)
Jerbi, Amal& Mosset, Paul& Gree, Rene& Kammoun, Majed. 2019. Selective modification of oleuropein, a multifunctional bioactive natural product. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1049-1059.
https://search.emarefa.net/detail/BIM-1443203
Modern Language Association (MLA)
Jerbi, Amal…[et al.]. Selective modification of oleuropein, a multifunctional bioactive natural product. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1049-1059.
https://search.emarefa.net/detail/BIM-1443203
American Medical Association (AMA)
Jerbi, Amal& Mosset, Paul& Gree, Rene& Kammoun, Majed. Selective modification of oleuropein, a multifunctional bioactive natural product. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1049-1059.
https://search.emarefa.net/detail/BIM-1443203
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1057-1059
Record ID
BIM-1443203