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Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients
المؤلفون المشاركون
Kalarikkal, Nandakumar
Jose, Jiya
Nair, Anju K.
Oluwafemi, Oluwatobi
Thomas, Sabu
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 23، العدد 8 (31 ديسمبر/كانون الأول 2019)، ص ص. 1090-1101، 12ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
السعودية
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
blood stream infections in the cancer patients are a critical problem which leads to considerable rate of mortality and morbidity.
In view of this herein, we account the response of Poly Vinyl Pyrrolidone (PVP) coated silver nanowires (Ag-NWs) and silver nano cubes (Ag-NCs) towards carbapenem (Escherichia coli) and vancomycin (Staphylococcus aureus) resistant strains as well as to human epithelial cells.
The prepared PVP capped silver nanomaterials were in the range of 80 nm (Ag-NC) and 25 nm (Ag-NW) as observed from Transmission Electron Microscopy (TEM).
Though the selected strains were resistant to carbapenem and vancomycin, PVP capped Ag-NWs and Ag-NCs could inhibit the growth of these strains.
These nanomaterials could break the cell wall and damage the genetic material of these strains as observed by death rate assay and alkaline comet assay.
Furthermore, we have shown that toxicity of Ag-NWs and Ag-NCs precisely follows the dose retort pattern.
Even though the resistant strains were susceptible to a concentration of 10 mg ml 1 of silver nanomaterials the epithelial cells were not affected by the same concentration.
It is also confirmed with live dead staining assay and observed that metabolic activities of epithelial cells were not affected by a concentration of 10 mg ml 1 .
Overall, this work suggests that these nanomaterials can be utilized to treat the multiple drug resistant strains from cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jose, Jiya& Nair, Anju K.& Kalarikkal, Nandakumar& Oluwafemi, Oluwatobi& Thomas, Sabu. 2019. Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1090-1101.
https://search.emarefa.net/detail/BIM-1443213
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jose, Jiya…[et al.]. Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1090-1101.
https://search.emarefa.net/detail/BIM-1443213
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jose, Jiya& Nair, Anju K.& Kalarikkal, Nandakumar& Oluwafemi, Oluwatobi& Thomas, Sabu. Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1090-1101.
https://search.emarefa.net/detail/BIM-1443213
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1098-1101
رقم السجل
BIM-1443213
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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