Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients
Joint Authors
Kalarikkal, Nandakumar
Jose, Jiya
Nair, Anju K.
Oluwafemi, Oluwatobi
Thomas, Sabu
Source
Journal of Saudi Chemical Society
Issue
Vol. 23, Issue 8 (31 Dec. 2019), pp.1090-1101, 12 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Abstract EN
blood stream infections in the cancer patients are a critical problem which leads to considerable rate of mortality and morbidity.
In view of this herein, we account the response of Poly Vinyl Pyrrolidone (PVP) coated silver nanowires (Ag-NWs) and silver nano cubes (Ag-NCs) towards carbapenem (Escherichia coli) and vancomycin (Staphylococcus aureus) resistant strains as well as to human epithelial cells.
The prepared PVP capped silver nanomaterials were in the range of 80 nm (Ag-NC) and 25 nm (Ag-NW) as observed from Transmission Electron Microscopy (TEM).
Though the selected strains were resistant to carbapenem and vancomycin, PVP capped Ag-NWs and Ag-NCs could inhibit the growth of these strains.
These nanomaterials could break the cell wall and damage the genetic material of these strains as observed by death rate assay and alkaline comet assay.
Furthermore, we have shown that toxicity of Ag-NWs and Ag-NCs precisely follows the dose retort pattern.
Even though the resistant strains were susceptible to a concentration of 10 mg ml 1 of silver nanomaterials the epithelial cells were not affected by the same concentration.
It is also confirmed with live dead staining assay and observed that metabolic activities of epithelial cells were not affected by a concentration of 10 mg ml 1 .
Overall, this work suggests that these nanomaterials can be utilized to treat the multiple drug resistant strains from cancer patients.
American Psychological Association (APA)
Jose, Jiya& Nair, Anju K.& Kalarikkal, Nandakumar& Oluwafemi, Oluwatobi& Thomas, Sabu. 2019. Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1090-1101.
https://search.emarefa.net/detail/BIM-1443213
Modern Language Association (MLA)
Jose, Jiya…[et al.]. Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1090-1101.
https://search.emarefa.net/detail/BIM-1443213
American Medical Association (AMA)
Jose, Jiya& Nair, Anju K.& Kalarikkal, Nandakumar& Oluwafemi, Oluwatobi& Thomas, Sabu. Novel bio compactable silver nanowires and nanocubes: an effective treatment against carbapenem and vancomycin resistant strains isolated from cancer patients. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1090-1101.
https://search.emarefa.net/detail/BIM-1443213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1098-1101
Record ID
BIM-1443213