Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats
المؤلفون المشاركون
Nada, Ahmad
al-Shaykhali, Nur al-Din Amin
Ibrahim, Dua
Arafah, Nura
Qandil, Iman Ibrahim
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 56، العدد 3 (30 إبريل/نيسان 2023)، ص ص. 41-52، 12ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2023-04-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Seleno-compounds have gained a significant consideration due to their efficiency as chemotherapeutic agents.
the aim of the current work was to elucidate the impact of “Ebselen” on Diethylnitrosamine-initiated hepatocarcinogenesis in male albino rats.
hepatocellular carcinoma was initiated with oral supplementation of diethylnitrosamine (DEN] (15mg / kg body-weight) for 2 months.
Ebselen (5mg / kg body-weight) was orally given to rats for 2 months after DEN-administration.
Biochemical analysis includes assessment of liver functions (ALT & AST activities), kidney functions (urea and creatinine), determination of reduced glutathione (GSH) and malondialdehyde (MDA) contents in liver tissues [oxidative stress markers], alfa-fetoprotein (AFP) (tumor marker), besides Bcl2 expression and caspase-3 activities (apoptotic markers).
the level of some essential trace elements (iron, zinc, copper, calcium and manganese) was also measured.
the results revealed the powerful capacity of ebselen in minimizing the changes induced by DEN verified by significant increment in the level of hepatic antioxidant GSH accompanied by a marked decline in MDA concentration (marker of lipid peroxidation).
also, ebselen-treatment decreases ALT & AST activities, urea and creatinine concentrations.
the increase of AFP, Bcl2 and the decrease of caspase-3 were less marked.
the increase of Fe, Ca and Cu, the decrease of Zn and Mn were improved, compared to DEN-group.
Histopathological examinations of hepatocyte cells were in accordance with the biochemical results confirming the potential role of ebselen in minimizing DNE-induced damage.
Ebselen-treatment improved the harmful impacts initiated by DEN as it is an effective antioxidant and scavenger of free toxic radicals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arafah, Nura& Ibrahim, Dua& Qandil, Iman Ibrahim& Nada, Ahmad& al-Shaykhali, Nur al-Din Amin. 2023. Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats. Arab Journal of Nuclear Sciences and Applications،Vol. 56, no. 3, pp.41-52.
https://search.emarefa.net/detail/BIM-1460422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arafah, Nura…[et al.]. Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats. Arab Journal of Nuclear Sciences and Applications Vol. 56, no. 3 (Apr. 2023), pp.41-52.
https://search.emarefa.net/detail/BIM-1460422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arafah, Nura& Ibrahim, Dua& Qandil, Iman Ibrahim& Nada, Ahmad& al-Shaykhali, Nur al-Din Amin. Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats. Arab Journal of Nuclear Sciences and Applications. 2023. Vol. 56, no. 3, pp.41-52.
https://search.emarefa.net/detail/BIM-1460422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 50-52
رقم السجل
BIM-1460422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر