Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats
Joint Authors
Nada, Ahmad
al-Shaykhali, Nur al-Din Amin
Ibrahim, Dua
Arafah, Nura
Qandil, Iman Ibrahim
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 56, Issue 3 (30 Apr. 2023), pp.41-52, 12 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2023-04-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Topics
Abstract EN
Seleno-compounds have gained a significant consideration due to their efficiency as chemotherapeutic agents.
the aim of the current work was to elucidate the impact of “Ebselen” on Diethylnitrosamine-initiated hepatocarcinogenesis in male albino rats.
hepatocellular carcinoma was initiated with oral supplementation of diethylnitrosamine (DEN] (15mg / kg body-weight) for 2 months.
Ebselen (5mg / kg body-weight) was orally given to rats for 2 months after DEN-administration.
Biochemical analysis includes assessment of liver functions (ALT & AST activities), kidney functions (urea and creatinine), determination of reduced glutathione (GSH) and malondialdehyde (MDA) contents in liver tissues [oxidative stress markers], alfa-fetoprotein (AFP) (tumor marker), besides Bcl2 expression and caspase-3 activities (apoptotic markers).
the level of some essential trace elements (iron, zinc, copper, calcium and manganese) was also measured.
the results revealed the powerful capacity of ebselen in minimizing the changes induced by DEN verified by significant increment in the level of hepatic antioxidant GSH accompanied by a marked decline in MDA concentration (marker of lipid peroxidation).
also, ebselen-treatment decreases ALT & AST activities, urea and creatinine concentrations.
the increase of AFP, Bcl2 and the decrease of caspase-3 were less marked.
the increase of Fe, Ca and Cu, the decrease of Zn and Mn were improved, compared to DEN-group.
Histopathological examinations of hepatocyte cells were in accordance with the biochemical results confirming the potential role of ebselen in minimizing DNE-induced damage.
Ebselen-treatment improved the harmful impacts initiated by DEN as it is an effective antioxidant and scavenger of free toxic radicals.
American Psychological Association (APA)
Arafah, Nura& Ibrahim, Dua& Qandil, Iman Ibrahim& Nada, Ahmad& al-Shaykhali, Nur al-Din Amin. 2023. Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats. Arab Journal of Nuclear Sciences and Applications،Vol. 56, no. 3, pp.41-52.
https://search.emarefa.net/detail/BIM-1460422
Modern Language Association (MLA)
Arafah, Nura…[et al.]. Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats. Arab Journal of Nuclear Sciences and Applications Vol. 56, no. 3 (Apr. 2023), pp.41-52.
https://search.emarefa.net/detail/BIM-1460422
American Medical Association (AMA)
Arafah, Nura& Ibrahim, Dua& Qandil, Iman Ibrahim& Nada, Ahmad& al-Shaykhali, Nur al-Din Amin. Modulatory impact of ebselen against diethylnitrosamine initiated hepatocarcinogenesis in rats. Arab Journal of Nuclear Sciences and Applications. 2023. Vol. 56, no. 3, pp.41-52.
https://search.emarefa.net/detail/BIM-1460422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 50-52
Record ID
BIM-1460422