Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies

المؤلفون المشاركون

Mahardani, Putu Nandika
Wati, Putu Nandika
Siloam, Azriel
Savitri, Ni Putu Ayu
Manggala, Arya Krisna

المصدر

Oman Medical Journal

العدد

المجلد 37، العدد 1 (31 يناير/كانون الثاني 2022)11ص.

الناشر

المجلس العماني للاختصاصات الطبية

تاريخ النشر

2022-01-31

دولة النشر

سلطنة عمان

عدد الصفحات

11

التخصصات الرئيسية

العلوم الطبية والصيدلة والعلوم الصحية

الملخص EN

This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB).

We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR.

Seven cohort studies were selected from 314 studies.

The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR TB with success rates above 50% in respective studies.

The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide gatifloxacin in the intensive phase for four months and clofazimine-ethambutol pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months.

Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects.

STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Mahardani, Putu Nandika; Putu Nandika Mahardani& Dyah Kanya Wati; Wati, Putu Nandika& Azriel Siloam; Siloam, Azriel& Ni Putu Ayu Savitri; Savitri, Ni Putu Ayu& Arya Krisna Manggala; Manggala, Arya Krisna. 2022. Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies. Oman Medical Journal،Vol. 37, no. 1.
https://search.emarefa.net/detail/BIM-1492236

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Siloam, Azriel…[et al.]. Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies. Oman Medical Journal Vol. 37, no. 1 (Jan. 2022).
https://search.emarefa.net/detail/BIM-1492236

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Mahardani, Putu Nandika; Putu Nandika Mahardani& Dyah Kanya Wati; Wati, Putu Nandika& Azriel Siloam; Siloam, Azriel& Ni Putu Ayu Savitri; Savitri, Ni Putu Ayu& Arya Krisna Manggala; Manggala, Arya Krisna. Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies. Oman Medical Journal. 2022. Vol. 37, no. 1.
https://search.emarefa.net/detail/BIM-1492236

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes appendices.

رقم السجل

BIM-1492236