Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies
Joint Authors
Mahardani, Putu Nandika
Wati, Putu Nandika
Siloam, Azriel
Savitri, Ni Putu Ayu
Manggala, Arya Krisna
Source
Issue
Vol. 37, Issue 1 (31 Jan. 2022)11 p.
Publisher
Publication Date
2022-01-31
Country of Publication
Oman
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB).
We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR.
Seven cohort studies were selected from 314 studies.
The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR TB with success rates above 50% in respective studies.
The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide gatifloxacin in the intensive phase for four months and clofazimine-ethambutol pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months.
Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects.
STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration.
American Psychological Association (APA)
Mahardani, Putu Nandika; Putu Nandika Mahardani& Dyah Kanya Wati; Wati, Putu Nandika& Azriel Siloam; Siloam, Azriel& Ni Putu Ayu Savitri; Savitri, Ni Putu Ayu& Arya Krisna Manggala; Manggala, Arya Krisna. 2022. Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies. Oman Medical Journal،Vol. 37, no. 1.
https://search.emarefa.net/detail/BIM-1492236
Modern Language Association (MLA)
Siloam, Azriel…[et al.]. Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies. Oman Medical Journal Vol. 37, no. 1 (Jan. 2022).
https://search.emarefa.net/detail/BIM-1492236
American Medical Association (AMA)
Mahardani, Putu Nandika; Putu Nandika Mahardani& Dyah Kanya Wati; Wati, Putu Nandika& Azriel Siloam; Siloam, Azriel& Ni Putu Ayu Savitri; Savitri, Ni Putu Ayu& Arya Krisna Manggala; Manggala, Arya Krisna. Effectiveness and safety of short-term regimen for multidrug-resistant tuberculosis treatment : a systematic review of cohort studies. Oman Medical Journal. 2022. Vol. 37, no. 1.
https://search.emarefa.net/detail/BIM-1492236
Data Type
Journal Articles
Language
English
Notes
Includes appendices.
Record ID
BIM-1492236