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Processes of 1,3-Dipolar cycloaddition in nucleoside, nucleotide and bio conjugation and its importance in medicinal chemistry
المؤلفون المشاركون
Abbas, Sahar Fadil
Karim, Asil Fadil
Mubarak, Hayfa A.
Ulwan, Hamid Husayn
المصدر
al-Kufa University Journal for Biology
العدد
المجلد 15، العدد 1 (31 مارس/آذار 2023)، ص ص. 35-44، 10ص.
الناشر
جامعة الكوفة كلية العلوم قسم علوم الحياة
تاريخ النشر
2023-03-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In the 1,3-dipolar cycloaddition, a 1,3-dipole and a dipolarophile interact chemically to produce a five-membered ring.
The Huisgen cycloaddition occurs when an organic azide and an alkyne unite to form a 1,3-dipolar cycloaddition that results in a 1,2,3-triazole.
1,3-dipolar cycloaddition is an essential step in the regio- and stereoselective synthesis of five-membered heterocycles and their ring-opened acyclic derivatives.
Some of the cycloadducts produced by these reactions were converted into enantiopure precursors known to exist in some biologically active chemicals as well as an active stereoisomer of a pine sawfly sex pheromone.
The synthesis of several new enantiopure organocatalysts that were shown to be helpful in some The synthetic utility of these 1,3-dipolar cycloaddition processes with nitrones and a,b-unsaturated aldehydes was further demonstrated.
There are times when these reactions have modest to moderate diastereofacial selectivity.
the choose actual and nonracemic have improved.
Compound collections are created in chemical biology research using the BIOS concept, which draws its inspiration from natural product scaffolds.
In BIOS, the primary criterion utilized to develop hypotheses for the design and synthesis of targeted chemical libraries is biological relevance.
Because they outline the chemical domains that nature has explored, the underlying scaffolds of natural product classes in particular serve as an inspiration for BIOS because they can be thought of as "trivet can often be achieved if both the azomethine ylide and the dipolarophile are chi privileged.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karim, Asil Fadil& Abbas, Sahar Fadil& Mubarak, Hayfa A.& Ulwan, Hamid Husayn. 2023. Processes of 1,3-Dipolar cycloaddition in nucleoside, nucleotide and bio conjugation and its importance in medicinal chemistry. al-Kufa University Journal for Biology،Vol. 15, no. 1, pp.35-44.
https://search.emarefa.net/detail/BIM-1495339
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karim, Asil Fadil…[et al.]. Processes of 1,3-Dipolar cycloaddition in nucleoside, nucleotide and bio conjugation and its importance in medicinal chemistry. al-Kufa University Journal for Biology Vol. 15, no. 1 (2023), pp.35-44.
https://search.emarefa.net/detail/BIM-1495339
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karim, Asil Fadil& Abbas, Sahar Fadil& Mubarak, Hayfa A.& Ulwan, Hamid Husayn. Processes of 1,3-Dipolar cycloaddition in nucleoside, nucleotide and bio conjugation and its importance in medicinal chemistry. al-Kufa University Journal for Biology. 2023. Vol. 15, no. 1, pp.35-44.
https://search.emarefa.net/detail/BIM-1495339
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 44
رقم السجل
BIM-1495339
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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