Processes of 1,3-Dipolar cycloaddition in nucleoside, nucleotide and bio conjugation and its importance in medicinal chemistry

Abstract EN

In the 1,3-dipolar cycloaddition, a 1,3-dipole and a dipolarophile interact chemically to produce a five-membered ring.

The Huisgen cycloaddition occurs when an organic azide and an alkyne unite to form a 1,3-dipolar cycloaddition that results in a 1,2,3-triazole.

1,3-dipolar cycloaddition is an essential step in the regio- and stereoselective synthesis of five-membered heterocycles and their ring-opened acyclic derivatives.

Some of the cycloadducts produced by these reactions were converted into enantiopure precursors known to exist in some biologically active chemicals as well as an active stereoisomer of a pine sawfly sex pheromone.

The synthesis of several new enantiopure organocatalysts that were shown to be helpful in some The synthetic utility of these 1,3-dipolar cycloaddition processes with nitrones and a,b-unsaturated aldehydes was further demonstrated.

There are times when these reactions have modest to moderate diastereofacial selectivity.

the choose actual and nonracemic have improved.

Compound collections are created in chemical biology research using the BIOS concept, which draws its inspiration from natural product scaffolds.

In BIOS, the primary criterion utilized to develop hypotheses for the design and synthesis of targeted chemical libraries is biological relevance.

Because they outline the chemical domains that nature has explored, the underlying scaffolds of natural product classes in particular serve as an inspiration for BIOS because they can be thought of as "trivet can often be achieved if both the azomethine ylide and the dipolarophile are chi privileged.