An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors
المؤلفون المشاركون
Iqbal, Sarush
Abrar, Shaziah
Mukhtar, Asma
Khan, Muhammad Zawar
Ahmad, Irfan
المصدر
العدد
المجلد 50، العدد 3 A (31 يوليو/تموز 2023)، ص ص. 1-12، 12ص.
الناشر
جامعة الكويت مجلس النشر العلمي
تاريخ النشر
2023-07-31
دولة النشر
الكويت
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
N",N"-Bis[(E)-phenylmethylidene]carbonic dihydrazide, azotic ligands with lone electron pairs, have wide range of applications in catalysis, medicine, corrosion, and analytical chemistry.
keeping this broad range of applications in view, we have developed a new green method for the rapid synthesis of N",N"-Bis[(E)-phenylmethylidene]carbonic dihydrazide and its derivatives.
by using a new protocol, a range of carbonic dihydrazides 1-22 has been synthesized in excellent yields.
all synthesized compounds have been characterized by elemental analyses, 'H-NMR, EI MS and HR-MS.
these carbonic dihydrazides have also been synthesized via conventional method.
on comparisons of new and conventional methods, it is evident that newly developed solvent-free method is more proficient, high yielding, and simple.
as protease inhibitors are known to inhibit not only proliferation of cancer cell lines but also to cure hepatitis C virus and HIV aids infections, therefore, all purified and characterized compounds have also been evaluated for their potential to act as in vitro a-chymotrypsin (an enzyme belongs to protease family) inhibitors.
among tested compounds, ten compounds have shown varying degree of a chymotrypsin inhibition potential.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iqbal, Sarush& Abrar, Shaziah& Mukhtar, Asma& Ahmad, Irfan& Khan, Muhammad Zawar. 2023. An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors. Kuwait Journal of Science،Vol. 50, no. 3 A, pp.1-12.
https://search.emarefa.net/detail/BIM-1501367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iqbal, Sarush…[et al.]. An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors. Kuwait Journal of Science Vol. 50, no. 3 A (Jul. 2023), pp.1-12.
https://search.emarefa.net/detail/BIM-1501367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iqbal, Sarush& Abrar, Shaziah& Mukhtar, Asma& Ahmad, Irfan& Khan, Muhammad Zawar. An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors. Kuwait Journal of Science. 2023. Vol. 50, no. 3 A, pp.1-12.
https://search.emarefa.net/detail/BIM-1501367
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 9-12.
رقم السجل
BIM-1501367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر