An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors
Joint Authors
Iqbal, Sarush
Abrar, Shaziah
Mukhtar, Asma
Khan, Muhammad Zawar
Ahmad, Irfan
Source
Issue
Vol. 50, Issue 3 A (31 Jul. 2023), pp.1-12, 12 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2023-07-31
Country of Publication
Kuwait
No. of Pages
12
Main Subjects
Abstract EN
N",N"-Bis[(E)-phenylmethylidene]carbonic dihydrazide, azotic ligands with lone electron pairs, have wide range of applications in catalysis, medicine, corrosion, and analytical chemistry.
keeping this broad range of applications in view, we have developed a new green method for the rapid synthesis of N",N"-Bis[(E)-phenylmethylidene]carbonic dihydrazide and its derivatives.
by using a new protocol, a range of carbonic dihydrazides 1-22 has been synthesized in excellent yields.
all synthesized compounds have been characterized by elemental analyses, 'H-NMR, EI MS and HR-MS.
these carbonic dihydrazides have also been synthesized via conventional method.
on comparisons of new and conventional methods, it is evident that newly developed solvent-free method is more proficient, high yielding, and simple.
as protease inhibitors are known to inhibit not only proliferation of cancer cell lines but also to cure hepatitis C virus and HIV aids infections, therefore, all purified and characterized compounds have also been evaluated for their potential to act as in vitro a-chymotrypsin (an enzyme belongs to protease family) inhibitors.
among tested compounds, ten compounds have shown varying degree of a chymotrypsin inhibition potential.
American Psychological Association (APA)
Iqbal, Sarush& Abrar, Shaziah& Mukhtar, Asma& Ahmad, Irfan& Khan, Muhammad Zawar. 2023. An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors. Kuwait Journal of Science،Vol. 50, no. 3 A, pp.1-12.
https://search.emarefa.net/detail/BIM-1501367
Modern Language Association (MLA)
Iqbal, Sarush…[et al.]. An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors. Kuwait Journal of Science Vol. 50, no. 3 A (Jul. 2023), pp.1-12.
https://search.emarefa.net/detail/BIM-1501367
American Medical Association (AMA)
Iqbal, Sarush& Abrar, Shaziah& Mukhtar, Asma& Ahmad, Irfan& Khan, Muhammad Zawar. An efficient synthesis of N'', N'''-Bis[(E)-phenylmethylidene]carbonic dihydrazide derivatives and their evaluation as α-chymotrypsin nhibitors. Kuwait Journal of Science. 2023. Vol. 50, no. 3 A, pp.1-12.
https://search.emarefa.net/detail/BIM-1501367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-12.
Record ID
BIM-1501367