Transplacental passage of igg as a possible factor in pregnancy loss and initiation of labor

الملخص EN

Objective: To study the role of the transplacental passage of IgG in the initiation of labor or pregnancy loss.

Materials, and Methods: 62 women with spontaneous normal labor and 60 with elective Caesarean section at a large university hospital in Baghdad, Iraq were placed in a prospective study.

Sections of the placenta were prepared with a cryostat at 30oC, stained with a locally modified direct immunofluorescent technique, and studied with an irhmunofluorescent microscope to determine the density of IgG deposition.

The density was then quantified on a scale of 1-4.

Results: Immunofluorescent scores of IgG deposition in trophoblastic tissue were higher in cases of spontaneous labor (3.2 0.1) than in cases delivered electively before the onset of spontaneous labor (1.9 0.1, P<0.0001).

Linear regression revealed a significant increase in antibody deposition with advancing gestational age in both groups, being more clear in the spontaneous labor than in the elective Caesarean section group (r=0.6, Vs r=0.4, P=0.001) Conclusion: Higher IgG deposition was found in placental tissue as gestational age advanced.

At the point of highest IgG deposition, labor began.

This may suggest a role for transplacental IgG in the initiation of labor or earlier pregnancy loss.