A food additive formula to minimize the negative effects due to ingesting aflatoxins(s)‎ contaminated food

الملخص EN

This study is an attempt to prevent or minimize the negative probabilities due to ingesting Aflatoxin (s) contaminated food.

A previous research studies for about 30 years leads to suggest this studied formula.

Data revealed that the proposed- formula had positive effects when added to aflatoxin(s) contaminated diets at concentrations of 0.1 and 0.2% (w / w).

An exposure study extended for 3 different stages was conducted using both sexes of white albino rats.

The 1st stage (pre-treatment) was suggested to compare the performance of animal groupings under the normal conditions before receiving any treatment, either level of contamination(s) or dosage(s) of additive, such stage extended for 2 weeks.

The 2nd stage treatment), the animals received different levels of aflatoxin (s) and the studied formula, such stage extended for 4 weeks.

The 3rd stage (post-treatment) was suggested to transfer treated animal groupings to receive sound diets free from any level of contamination.

The averages of body weight and body weight gain were dramatically affected during the exposure stage to aflatoxins.

The studied formula prevents the deterioration of such performance which obviously observed in animal grouping received high level of contamination.

Both males and females were responding to contaminated diets and to the additive as well.

The activities of GOT and GPT enzymes, which are reflecting liver function, were obviously-affected during exposure to aflatoxins, but such levels came back to normal during post-treatment stage.

Histochemical studies and the semi-quantitative data exhibited that both NADH-diaphorase and mitochondrial ATPase were severely affected when the treated animals ingested aflatoxins and such severe effects came back to moderate when receiving the proposed additive.

Also, the histo pathological changes of congestion, necrosis, degeneration and mono-nuclear cell infiltration were obviously observed in livers of both sexes of treated animals.

Such histopathological changes were not observed in livers of rats received the studied additive simultaneously with the aflatoxin(s)-contaminated diets.

It's worthy to mention that the studied formula was registered as a patent in the Egyptian Academy of Science and Technology under the name of "mycodote" and application number 20370 / 6.