Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity
المؤلفون المشاركون
Duwaydar, Ahmad M.
Abd al-Fattah, Muhammad I.
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 35، العدد 1 (31 يناير/كانون الثاني 2008)، ص ص. 21-28، 8ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2008-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective : Auto antibodies against C-reactive protein (anti-CRP) were measured and correlated with disease activity measures in serum samples from 25 patients with systemic lupus erythematosus (SLE).
Methodology : Two samples were collected from each patient, one during the control state and the other during disease flare according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).
The presence of anti-CRP was analysed with enzyme-linked immunosorbent assay (ELISA).
The cut-off for positive anti-CRP test was set at the 95th centile of 100 healthy blood donor sera.
Serum levels of CRP, anti-DNA antibodies, complement components and blood cell counts were evaluated in the two samples of each patient.
Results : Of the fifty serum samples, 20 (40%) contained antibodies reactive with monomeric CRP, and all patients with active lupus nephritis were positive for anti-CRP at flare.
Anti-CRP data from all patients were positively correlated with SLEDAI scores and anti-DNA antibody levels, whereas significant inverse relationships were noted for complement factors C1 q, C 3 and C 4, and for lymphocyte counts.
Conclusion : This study confirms the high prevalence of anti-CRP autoantibodies in SLE and that the antibody levels are correlated with clinical and laboratory disease activity measures.
This indicates that anti-CRP antibodies might have biological functions in the pathogenesis of SLE.
Further clinical and experimental studies on effects mediated by anti-CRP antibodies are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duwaydar, Ahmad M.& Abd al-Fattah, Muhammad I.. 2008. Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 35, no. 1, pp.21-28.
https://search.emarefa.net/detail/BIM-26585
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duwaydar, Ahmad M.& Abd al-Fattah, Muhammad I.. Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 35, no. 1 (Jan. 2008), pp.21-28.
https://search.emarefa.net/detail/BIM-26585
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duwaydar, Ahmad M.& Abd al-Fattah, Muhammad I.. Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity. Egyptian Rheumatology and Rehabilitation. 2008. Vol. 35, no. 1, pp.21-28.
https://search.emarefa.net/detail/BIM-26585
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 26-28
رقم السجل
BIM-26585
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر