Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity
Joint Authors
Duwaydar, Ahmad M.
Abd al-Fattah, Muhammad I.
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 35, Issue 1 (31 Jan. 2008), pp.21-28, 8 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2008-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Objective : Auto antibodies against C-reactive protein (anti-CRP) were measured and correlated with disease activity measures in serum samples from 25 patients with systemic lupus erythematosus (SLE).
Methodology : Two samples were collected from each patient, one during the control state and the other during disease flare according to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI).
The presence of anti-CRP was analysed with enzyme-linked immunosorbent assay (ELISA).
The cut-off for positive anti-CRP test was set at the 95th centile of 100 healthy blood donor sera.
Serum levels of CRP, anti-DNA antibodies, complement components and blood cell counts were evaluated in the two samples of each patient.
Results : Of the fifty serum samples, 20 (40%) contained antibodies reactive with monomeric CRP, and all patients with active lupus nephritis were positive for anti-CRP at flare.
Anti-CRP data from all patients were positively correlated with SLEDAI scores and anti-DNA antibody levels, whereas significant inverse relationships were noted for complement factors C1 q, C 3 and C 4, and for lymphocyte counts.
Conclusion : This study confirms the high prevalence of anti-CRP autoantibodies in SLE and that the antibody levels are correlated with clinical and laboratory disease activity measures.
This indicates that anti-CRP antibodies might have biological functions in the pathogenesis of SLE.
Further clinical and experimental studies on effects mediated by anti-CRP antibodies are warranted.
American Psychological Association (APA)
Duwaydar, Ahmad M.& Abd al-Fattah, Muhammad I.. 2008. Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity. Egyptian Rheumatology and Rehabilitation،Vol. 35, no. 1, pp.21-28.
https://search.emarefa.net/detail/BIM-26585
Modern Language Association (MLA)
Duwaydar, Ahmad M.& Abd al-Fattah, Muhammad I.. Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity. Egyptian Rheumatology and Rehabilitation Vol. 35, no. 1 (Jan. 2008), pp.21-28.
https://search.emarefa.net/detail/BIM-26585
American Medical Association (AMA)
Duwaydar, Ahmad M.& Abd al-Fattah, Muhammad I.. Serum monomeric C-Reactive protein autoantibodies in systemic lupus erythematosus and its correlation with disease activity. Egyptian Rheumatology and Rehabilitation. 2008. Vol. 35, no. 1, pp.21-28.
https://search.emarefa.net/detail/BIM-26585
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 26-28
Record ID
BIM-26585