Hemoglobin d (hb d punjab los angeles and hb d Iran)‎ and co-inheritance with alpha- and beta- thalassemia in southern Iran

المؤلفون المشاركون

Zakerinia, M.
Ayato Allah, M.
Rastegar, M.
Amanat, sh.
Askarinejad, A. R.
Amirghofran, S.
Haghshenas, M.

المصدر

Iranian Red Crescent Medical Journal

العدد

المجلد 13، العدد 7 (31 يوليو/تموز 2011)، ص ص. 493-498، 6ص.

الناشر

المستشفى الإيراني

تاريخ النشر

2011-07-31

دولة النشر

الإمارات العربية المتحدة

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Background : hemoglobin-D (Hb D) is an uncommon structural hemoglobin variant, which is reported to be prevalent in north western India.

There are only a few small series, of this entity in the literature.

We report the largest single center experience on this entity from Iran.

Methods : between November 2002 and December 2010 as a result of screening premarital for beta-thalassemia in Shiraz, Fars Province, Southern Iran, column chromatography, Hb electrophoresis, solubility test, and / or high performance liquid chromatography (HPLC), direct sequencing and restriction analysis were used for hemoglobinopathies and structural Hb variants.

The data of 220 subjects with Hb D variants are analyzed in this report.

Results : These comprised of 180 carries of Hb D; 92 cases of Hb D Punjab/Los Angeles (b121Glutamic acid Glutamine) and 88 subjects with Hb D Iran (β 22 Glu®Gln), 3 homozygous cases for Hb D, 17 subjects with beta-thalassemia- Hb D, 12 with Hb D- alpha- thalassemia- 1, 3 homozygous Hb D- alpha thalassemia- 1 trait, one with Hb D Punjab-sickle cell anemia, and two with Hb D Iran / sickle cell anemia.

Conclusion : the carriers of Hb D and homozygous cases for Hb D were not anemic and had normal red blood cell morphology, as they are not usually detected.

If Hb D was inherited in combination with thalassemia, the subjects had mild anemia and in some of them, the spleen was palpable (1-2 cm).

Co-inheritance of alpha thalassemia and Hb D resulted in the slightly higher Hb level and lower Hb D level as compared to Hb D / beta-thalassemia cases (Hb D 24-37% vs 57-88%).

Co inheritance of Hb D and sickle cell results was moderate to severe hemolytic anemia.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zakerinia, M.& Ayato Allah, M.& Rastegar, M.& Amanat, sh.& Askarinejad, A. R.& Amirghofran, S.…[et al.]. 2011. Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran. Iranian Red Crescent Medical Journal،Vol. 13, no. 7, pp.493-498.
https://search.emarefa.net/detail/BIM-268112

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zakerinia, M.…[et al.]. Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran. Iranian Red Crescent Medical Journal Vol. 13, no. 7 (Jul. 2011), pp.493-498.
https://search.emarefa.net/detail/BIM-268112

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zakerinia, M.& Ayato Allah, M.& Rastegar, M.& Amanat, sh.& Askarinejad, A. R.& Amirghofran, S.…[et al.]. Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 7, pp.493-498.
https://search.emarefa.net/detail/BIM-268112

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 497-498

رقم السجل

BIM-268112