Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran
Joint Authors
Zakerinia, M.
Ayato Allah, M.
Rastegar, M.
Amanat, sh.
Askarinejad, A. R.
Amirghofran, S.
Haghshenas, M.
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 13, Issue 7 (31 Jul. 2011), pp.493-498, 6 p.
Publisher
Publication Date
2011-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : hemoglobin-D (Hb D) is an uncommon structural hemoglobin variant, which is reported to be prevalent in north western India.
There are only a few small series, of this entity in the literature.
We report the largest single center experience on this entity from Iran.
Methods : between November 2002 and December 2010 as a result of screening premarital for beta-thalassemia in Shiraz, Fars Province, Southern Iran, column chromatography, Hb electrophoresis, solubility test, and / or high performance liquid chromatography (HPLC), direct sequencing and restriction analysis were used for hemoglobinopathies and structural Hb variants.
The data of 220 subjects with Hb D variants are analyzed in this report.
Results : These comprised of 180 carries of Hb D; 92 cases of Hb D Punjab/Los Angeles (b121Glutamic acid Glutamine) and 88 subjects with Hb D Iran (β 22 Glu®Gln), 3 homozygous cases for Hb D, 17 subjects with beta-thalassemia- Hb D, 12 with Hb D- alpha- thalassemia- 1, 3 homozygous Hb D- alpha thalassemia- 1 trait, one with Hb D Punjab-sickle cell anemia, and two with Hb D Iran / sickle cell anemia.
Conclusion : the carriers of Hb D and homozygous cases for Hb D were not anemic and had normal red blood cell morphology, as they are not usually detected.
If Hb D was inherited in combination with thalassemia, the subjects had mild anemia and in some of them, the spleen was palpable (1-2 cm).
Co-inheritance of alpha thalassemia and Hb D resulted in the slightly higher Hb level and lower Hb D level as compared to Hb D / beta-thalassemia cases (Hb D 24-37% vs 57-88%).
Co inheritance of Hb D and sickle cell results was moderate to severe hemolytic anemia.
American Psychological Association (APA)
Zakerinia, M.& Ayato Allah, M.& Rastegar, M.& Amanat, sh.& Askarinejad, A. R.& Amirghofran, S.…[et al.]. 2011. Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran. Iranian Red Crescent Medical Journal،Vol. 13, no. 7, pp.493-498.
https://search.emarefa.net/detail/BIM-268112
Modern Language Association (MLA)
Zakerinia, M.…[et al.]. Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran. Iranian Red Crescent Medical Journal Vol. 13, no. 7 (Jul. 2011), pp.493-498.
https://search.emarefa.net/detail/BIM-268112
American Medical Association (AMA)
Zakerinia, M.& Ayato Allah, M.& Rastegar, M.& Amanat, sh.& Askarinejad, A. R.& Amirghofran, S.…[et al.]. Hemoglobin d (hb d punjab los angeles and hb d Iran) and co-inheritance with alpha- and beta- thalassemia in southern Iran. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 7, pp.493-498.
https://search.emarefa.net/detail/BIM-268112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 497-498
Record ID
BIM-268112