Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters
المؤلفون المشاركون
Abd al-Hadi, Muna
al-Jundi, Saba
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 21، العدد 2 (30 يونيو/حزيران 2009)، ص ص. 139-149، 11ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2009-06-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Angiogenesis and lymph angiogenesis are essential for breast cancer growth and progression.
This study aimed at investigating lymphatic micro vessel density (LVD) and micro vessel density (MVD) as prognostic markers in breast carcinoma.
Forty breast carcinomas were immunostained for D2-40, CD31 and VEGF.
Median lymphatic and blood micro vessel densities, as well as VEGF expression, were related to each other and to clinic pathologic parameters including lymph node (LN) status.
The efficacy of haematoxylin and eosin (H & E) in detecting lymphatic vessel invasion (LVI) compared to D2-40 immunostaining was also investigated.
D2-40 stained normal lymphatic endothelium and my epithelial cells, but with different staining patterns.
D2-40 LVD related significantly to CD31 counts (r = 0.470 ; p = 0.002), and LN metastasis (Mann-Whitney U = 101.500; p = 0.043) ; however, it did not relate to age, tumor grade, tumor size or LVI.
D2-40 identified LVI in 3 more cases (7.5 %) than those detected by H & E.
VEGF was expressed in 85 % of cases, and was significantly related to CD31 and D2-40 counts (p = 0.033 and 0.007, respectively).
In conclusion, D2-40 LVD showed a significant association with LN metastasis, and can be considered to segregate patients with positive from those with negative LNs.
D2-40 enhances the detection of LVI relative to H&E staining reflecting a potential for lymphatic metastatic spread and possible poor prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Jundi, Saba& Abd al-Hadi, Muna. 2009. Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.139-149.
https://search.emarefa.net/detail/BIM-273986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Jundi, Saba& Abd al-Hadi, Muna. Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.139-149.
https://search.emarefa.net/detail/BIM-273986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Jundi, Saba& Abd al-Hadi, Muna. Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.139-149.
https://search.emarefa.net/detail/BIM-273986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 147-149
رقم السجل
BIM-273986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر