Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters
Joint Authors
Abd al-Hadi, Muna
al-Jundi, Saba
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 2 (30 Jun. 2009), pp.139-149, 11 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-06-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Angiogenesis and lymph angiogenesis are essential for breast cancer growth and progression.
This study aimed at investigating lymphatic micro vessel density (LVD) and micro vessel density (MVD) as prognostic markers in breast carcinoma.
Forty breast carcinomas were immunostained for D2-40, CD31 and VEGF.
Median lymphatic and blood micro vessel densities, as well as VEGF expression, were related to each other and to clinic pathologic parameters including lymph node (LN) status.
The efficacy of haematoxylin and eosin (H & E) in detecting lymphatic vessel invasion (LVI) compared to D2-40 immunostaining was also investigated.
D2-40 stained normal lymphatic endothelium and my epithelial cells, but with different staining patterns.
D2-40 LVD related significantly to CD31 counts (r = 0.470 ; p = 0.002), and LN metastasis (Mann-Whitney U = 101.500; p = 0.043) ; however, it did not relate to age, tumor grade, tumor size or LVI.
D2-40 identified LVI in 3 more cases (7.5 %) than those detected by H & E.
VEGF was expressed in 85 % of cases, and was significantly related to CD31 and D2-40 counts (p = 0.033 and 0.007, respectively).
In conclusion, D2-40 LVD showed a significant association with LN metastasis, and can be considered to segregate patients with positive from those with negative LNs.
D2-40 enhances the detection of LVI relative to H&E staining reflecting a potential for lymphatic metastatic spread and possible poor prognosis.
American Psychological Association (APA)
al-Jundi, Saba& Abd al-Hadi, Muna. 2009. Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.139-149.
https://search.emarefa.net/detail/BIM-273986
Modern Language Association (MLA)
al-Jundi, Saba& Abd al-Hadi, Muna. Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.139-149.
https://search.emarefa.net/detail/BIM-273986
American Medical Association (AMA)
al-Jundi, Saba& Abd al-Hadi, Muna. Lymphatic vessel density as prognostic factor in breast carcinoma : relation to clinicopathologic parameters. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.139-149.
https://search.emarefa.net/detail/BIM-273986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 147-149
Record ID
BIM-273986