Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results
المؤلفون المشاركون
Kamil, Ahmad I.
al-Baz, Ahmad G.
Abd al-Salam, Wail T.
Riyad, Mahmud E. al-Din
Mahena, Ahmad A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 21، العدد 2 (30 يونيو/حزيران 2009)، ص ص. 151-155، 5ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2009-06-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and Objectives: BCG has been used for more than 30 years and is currently the most effective agent for non-muscle invasive bladder cancer therapy after transurethral resection.
The high-grade T1 lesion treated by transurethral resection alone is reported to progress to muscle invasion in 30 % to 50 % of the patients.
Until now, optimal treatment schedule and optimal dose have not been defined as the toxicity related to BCG therapy is significant.
In this study we tried to evaluate the efficacy and toxicity of 60mg intravesical BCG (Pasteur strain) therapy in patients with T1 transitional cell carcinoma of the bladder.
Patients and Methods: From January 2000 till December 2007, 47 patients with single T1 transitional cell carcinoma (TCC) of the urinary bladder (grade 3 in 24 patients and grade 2 in 50 patients) were treated by complete transurethral resection followed by a 6-weeks course of 60mg BCG intravesically.
Follow-up ranged from 26-96 months with median of 61 months.
Results : Nine patients (12.1 %) exhibited recurrence with muscle invasion after 6-18 months (5 with grade 3 tumors and 4 with grade 2), all were subjected to radical cystectomy and urine diversion.
Whereas 19 patients (29.2 %)showed recurrent T1 tumor after 16-45 months (7with grade 3 tumors and 12 with grade 2) and were treated by TUR-T followed by a second 6-weeks course of 60mg BCG intravesically.
Recurrence index was 0.82 / 100 patients / month and the median tumor free period were 20 months.
Regarding toxicity ; irrigative symptoms occurred in 24 % of patients, fever in 9 %, microscopic hematuria in 14 % ; which appeared to be significantly low when compared with the rates reported for higher doses of BCG.
Conclusion : intravesical therapy of 60mg BCG is effective in prophylaxis against recurrence and progression of T1 TCC of the bladder.
Decreasing the dose resulted in reducing the side effects significantly without delay or cessation of therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamil, Ahmad I.& al-Baz, Ahmad G.& Abd al-Salam, Wail T.& Riyad, Mahmud E. al-Din& Mahena, Ahmad A.. 2009. Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.151-155.
https://search.emarefa.net/detail/BIM-273993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamil, Ahmad I.…[et al.]. Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.151-155.
https://search.emarefa.net/detail/BIM-273993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamil, Ahmad I.& al-Baz, Ahmad G.& Abd al-Salam, Wail T.& Riyad, Mahmud E. al-Din& Mahena, Ahmad A.. Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.151-155.
https://search.emarefa.net/detail/BIM-273993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 154-155
رقم السجل
BIM-273993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر