Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results
Joint Authors
Kamil, Ahmad I.
al-Baz, Ahmad G.
Abd al-Salam, Wail T.
Riyad, Mahmud E. al-Din
Mahena, Ahmad A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 2 (30 Jun. 2009), pp.151-155, 5 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background and Objectives: BCG has been used for more than 30 years and is currently the most effective agent for non-muscle invasive bladder cancer therapy after transurethral resection.
The high-grade T1 lesion treated by transurethral resection alone is reported to progress to muscle invasion in 30 % to 50 % of the patients.
Until now, optimal treatment schedule and optimal dose have not been defined as the toxicity related to BCG therapy is significant.
In this study we tried to evaluate the efficacy and toxicity of 60mg intravesical BCG (Pasteur strain) therapy in patients with T1 transitional cell carcinoma of the bladder.
Patients and Methods: From January 2000 till December 2007, 47 patients with single T1 transitional cell carcinoma (TCC) of the urinary bladder (grade 3 in 24 patients and grade 2 in 50 patients) were treated by complete transurethral resection followed by a 6-weeks course of 60mg BCG intravesically.
Follow-up ranged from 26-96 months with median of 61 months.
Results : Nine patients (12.1 %) exhibited recurrence with muscle invasion after 6-18 months (5 with grade 3 tumors and 4 with grade 2), all were subjected to radical cystectomy and urine diversion.
Whereas 19 patients (29.2 %)showed recurrent T1 tumor after 16-45 months (7with grade 3 tumors and 12 with grade 2) and were treated by TUR-T followed by a second 6-weeks course of 60mg BCG intravesically.
Recurrence index was 0.82 / 100 patients / month and the median tumor free period were 20 months.
Regarding toxicity ; irrigative symptoms occurred in 24 % of patients, fever in 9 %, microscopic hematuria in 14 % ; which appeared to be significantly low when compared with the rates reported for higher doses of BCG.
Conclusion : intravesical therapy of 60mg BCG is effective in prophylaxis against recurrence and progression of T1 TCC of the bladder.
Decreasing the dose resulted in reducing the side effects significantly without delay or cessation of therapy.
American Psychological Association (APA)
Kamil, Ahmad I.& al-Baz, Ahmad G.& Abd al-Salam, Wail T.& Riyad, Mahmud E. al-Din& Mahena, Ahmad A.. 2009. Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.151-155.
https://search.emarefa.net/detail/BIM-273993
Modern Language Association (MLA)
Kamil, Ahmad I.…[et al.]. Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.151-155.
https://search.emarefa.net/detail/BIM-273993
American Medical Association (AMA)
Kamil, Ahmad I.& al-Baz, Ahmad G.& Abd al-Salam, Wail T.& Riyad, Mahmud E. al-Din& Mahena, Ahmad A.. Low dose BCG regimen in T1 transitional cell carcinoma of the bladder : long term results. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.151-155.
https://search.emarefa.net/detail/BIM-273993
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 154-155
Record ID
BIM-273993