Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats
المؤلفون المشاركون
Abd al-Ghani, Ahmad A.
Abd al-Rahim, Ihab Talat Ahmad
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 21، العدد 2 (30 يونيو/حزيران 2009)، ص ص. 175-184، 10ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2009-06-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الموضوعات
الملخص EN
Background: Doxorubicin (DOX) is a potent chemotherapeutic agent used in the treatment of several tumors but its cardiac toxicity prevents its use at a maximum dose, representing an important problem.
Increased reactive oxygen species (ROS) and imbalance in nitric oxide (NO) production have been implicated in the cardio toxicity of doxorubicin.
Hesperidin is a citrus bioflavonoid that possesses a potent antioxidant and NO modulating activities.
Objectives : therefore, the aim of this study was to investigate the possible protective role of hesperidin against doxorubicin-induced cardiac toxicity.
Methods : Four groups of animals were used in this study.
First group served as a control and injected with the vehicle.
Second group was given 200 mg / kg of hesperidin orally for seven consecutive days.
The third group was injected with a single dose (20 mg / kg) of doxorubicin intraperitoneally and was sacrificed after 48 h.
The fourth group was treated with hesperidin for seven days but on day five, 1-hour after hesperidin treatment, rats were injected with the single dose of doxorubicin.
On day seven, the rats were scarified by decapitation.
Blood was collected and processed for determination of serum lactate dehydrogenase (LDH), creating kinase (CK) and NO.
The hearts were removed and processed for both histopathologically examination and determination of oxidative stress parameters like reduced glutathione (GSH), lipid peroxide (TBARS) levels and superoxide dismutase (SOD) activity.
Results : our results showed that doxorubicin produced severe cardio toxicity as indicated from increase in serum LDH, CK activities and NO level.
Histopathologically examination of DOX-treated rats revealed degenerative changes in heart tissues.
The significant decrease in GSH levels, SOD activity and increase in TBARS levels, indi-cated that DOX-induced cardio toxicity was mediated through ROS generation.
On the other hand, pretreatment of rats with hesperidin protected cardiac tissues against the cardio toxic effects of doxorubicin as evidenced from amelioration of histopathologically changes and normalization of cardiac biochemical parameters.
Conclusion : hesperidin may have a protective effect against DOX-induced cardio toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Rahim, Ihab Talat Ahmad& Abd al-Ghani, Ahmad A.. 2009. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.175-184.
https://search.emarefa.net/detail/BIM-274004
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Rahim, Ihab Talat Ahmad& Abd al-Ghani, Ahmad A.. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.175-184.
https://search.emarefa.net/detail/BIM-274004
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Rahim, Ihab Talat Ahmad& Abd al-Ghani, Ahmad A.. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.175-184.
https://search.emarefa.net/detail/BIM-274004
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 182-184
رقم السجل
BIM-274004
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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