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Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats
Joint Authors
Abd al-Ghani, Ahmad A.
Abd al-Rahim, Ihab Talat Ahmad
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 21, Issue 2 (30 Jun. 2009), pp.175-184, 10 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2009-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract EN
Background: Doxorubicin (DOX) is a potent chemotherapeutic agent used in the treatment of several tumors but its cardiac toxicity prevents its use at a maximum dose, representing an important problem.
Increased reactive oxygen species (ROS) and imbalance in nitric oxide (NO) production have been implicated in the cardio toxicity of doxorubicin.
Hesperidin is a citrus bioflavonoid that possesses a potent antioxidant and NO modulating activities.
Objectives : therefore, the aim of this study was to investigate the possible protective role of hesperidin against doxorubicin-induced cardiac toxicity.
Methods : Four groups of animals were used in this study.
First group served as a control and injected with the vehicle.
Second group was given 200 mg / kg of hesperidin orally for seven consecutive days.
The third group was injected with a single dose (20 mg / kg) of doxorubicin intraperitoneally and was sacrificed after 48 h.
The fourth group was treated with hesperidin for seven days but on day five, 1-hour after hesperidin treatment, rats were injected with the single dose of doxorubicin.
On day seven, the rats were scarified by decapitation.
Blood was collected and processed for determination of serum lactate dehydrogenase (LDH), creating kinase (CK) and NO.
The hearts were removed and processed for both histopathologically examination and determination of oxidative stress parameters like reduced glutathione (GSH), lipid peroxide (TBARS) levels and superoxide dismutase (SOD) activity.
Results : our results showed that doxorubicin produced severe cardio toxicity as indicated from increase in serum LDH, CK activities and NO level.
Histopathologically examination of DOX-treated rats revealed degenerative changes in heart tissues.
The significant decrease in GSH levels, SOD activity and increase in TBARS levels, indi-cated that DOX-induced cardio toxicity was mediated through ROS generation.
On the other hand, pretreatment of rats with hesperidin protected cardiac tissues against the cardio toxic effects of doxorubicin as evidenced from amelioration of histopathologically changes and normalization of cardiac biochemical parameters.
Conclusion : hesperidin may have a protective effect against DOX-induced cardio toxicity.
American Psychological Association (APA)
Abd al-Rahim, Ihab Talat Ahmad& Abd al-Ghani, Ahmad A.. 2009. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute،Vol. 21, no. 2, pp.175-184.
https://search.emarefa.net/detail/BIM-274004
Modern Language Association (MLA)
Abd al-Rahim, Ihab Talat Ahmad& Abd al-Ghani, Ahmad A.. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute Vol. 21, no. 2 (Jun. 2009), pp.175-184.
https://search.emarefa.net/detail/BIM-274004
American Medical Association (AMA)
Abd al-Rahim, Ihab Talat Ahmad& Abd al-Ghani, Ahmad A.. Hesperidin alleviates doxorubicin-induced cardiotoxicity in rats. Journal of the Egyptian National Cancer Institute. 2009. Vol. 21, no. 2, pp.175-184.
https://search.emarefa.net/detail/BIM-274004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 182-184
Record ID
BIM-274004