Dissolution enhancement of poorly water soluble drugs by co-precipitation in the presence of additives and stabilizers

الملخص EN

Mefenamic acid and Astemizole are models of drugs with poor aqueous solubility.

The dissolution rates of Mefenamic acid and Astemizole were enhanced by the precipitation of both drugs in the presence of aqueous surfactant (SAA) (Cremophor®) and polymer solution (PEG 20,000).

The highest dissolution rate for both drugs was achieved by precipitation in the presence of (Cremophor®), followed by precipitation in the presence of (PEG 20,000).

The precipitated crystals were characterized using IR, DSC, SEM and X-ray powder diffraction.

Mefenamic acid precipitates were of smaller size with no habit change, while in the case of astemizole there was a decrease in the crystallinity compared with the original powder.

No changes in the polymorphic forms for both drugs were noticed during precipitation process.