Dissolution enhancement of poorly water soluble drugs by co-precipitation in the presence of additives and stabilizers
Other Title(s)
تحسين ذوبان الأدوية ذات الانحلال المنخفض عن طريق ترسيبها في محاليل مائية بوجود السواغات و المثبثات
Joint Authors
Khanfar, Mayy Subhi
Salim, Mutazz al-Shaykh
Source
Jordan Journal of Pharmaceutical Sciences
Issue
Vol. 2, Issue 1 (31 Jan. 2009), pp.32-41, 10 p.
Publisher
University of Jordan Deanship of Academic Research (DAR)
Publication Date
2009-01-31
Country of Publication
Jordan
No. of Pages
10
Main Subjects
Topics
Abstract AR
حامض الميفناميك (Mefenamic Acid) و الأستيمازول (Astemizole) من الأمثلة على الأدوية ذات الذائبية القليلة بالماء.
معدل انحلال هذين الدوائين تحسن عن طريق ترسيبهما في الماء بوجود سواغات و متماثرات مختلفة مثل الكريموفور (Cremophor) و المحلول المبلمر (PEG 20000).
وجد أن أكبر معدل انحلال تم الحصول عليه كان بوجود الكريموفور (Cremophor) و تلاه المحلول المبلمر (PEG 20000).
تم دراسة البلورات المترسبة بواسطة أجهزة مختلفة مثل DSC,IR,SEM,X-RAY (diffraction).
وجد أن بلورات حامض الميفيناميك تميزت بصغر الحجم و لكن لم يتغير شكلها الخارجي بينما في حالة بلورات (Astemizole) كان هناك تغيير في مستوى التبلور مقارنة مع بودرة الاستيمازول.
لم يحدث أي تغيير في الشكل المتعدد للدوائين خلال عملية الترسيب.
Abstract EN
Mefenamic acid and Astemizole are models of drugs with poor aqueous solubility.
The dissolution rates of Mefenamic acid and Astemizole were enhanced by the precipitation of both drugs in the presence of aqueous surfactant (SAA) (Cremophor®) and polymer solution (PEG 20,000).
The highest dissolution rate for both drugs was achieved by precipitation in the presence of (Cremophor®), followed by precipitation in the presence of (PEG 20,000).
The precipitated crystals were characterized using IR, DSC, SEM and X-ray powder diffraction.
Mefenamic acid precipitates were of smaller size with no habit change, while in the case of astemizole there was a decrease in the crystallinity compared with the original powder.
No changes in the polymorphic forms for both drugs were noticed during precipitation process.
American Psychological Association (APA)
Khanfar, Mayy Subhi& Salim, Mutazz al-Shaykh. 2009. Dissolution enhancement of poorly water soluble drugs by co-precipitation in the presence of additives and stabilizers. Jordan Journal of Pharmaceutical Sciences،Vol. 2, no. 1, pp.32-41.
https://search.emarefa.net/detail/BIM-274529
Modern Language Association (MLA)
Khanfar, Mayy Subhi& Salim, Mutazz al-Shaykh. Dissolution enhancement of poorly water soluble drugs by co-precipitation in the presence of additives and stabilizers. Jordan Journal of Pharmaceutical Sciences Vol. 2, no. 1 (Jan. 2009), pp.32-41.
https://search.emarefa.net/detail/BIM-274529
American Medical Association (AMA)
Khanfar, Mayy Subhi& Salim, Mutazz al-Shaykh. Dissolution enhancement of poorly water soluble drugs by co-precipitation in the presence of additives and stabilizers. Jordan Journal of Pharmaceutical Sciences. 2009. Vol. 2, no. 1, pp.32-41.
https://search.emarefa.net/detail/BIM-274529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 39-40
Record ID
BIM-274529
