Genomic, proteomic and molecular model analyses of tmp kinase from some bloodparasitic protozoa. one-step forward in development of broad spectrum antiprotozoal drugs

الملخص EN

We had introduced TMP kinase as a new hopeful antiprotozoal drug target.

We provided theoretical model for the eligibility of TMP kinase from Plasmodium falciparum as a new drug target and we confirmed our assumption by experimental trials based on mutational, catalytic and molecular interference assays.

Here we extended our new antimicrobial model to include other blood protozoal infections as anaplasmosis and babesiosis.

Anaplamsa and babesia`s TMP kinase shows important structural differences which can be targeted to develop highly selective antiprotozoal drugs.

Therefore, we estimate that we are able to provide new broad spectrum antiprotozoal capable of binding the more than one parasitic species.

Furthermore, we investigated the inhibitory activity of one new compound capable of inhibiting the Plasmodium TMP kinase.