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Genomic, proteomic and molecular model analyses of tmp kinase from some bloodparasitic protozoa. one-step forward in development of broad spectrum antiprotozoal drugs
Joint Authors
Source
Kafr El-Sheikh Veterinary Medical Journal
Issue
Vol. 7, Issue 1 (31 May. 2009), pp.734-745, 12 p.
Publisher
Kafr El-Sheikh University Faculty of Veterinary Medicine
Publication Date
2009-05-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
We had introduced TMP kinase as a new hopeful antiprotozoal drug target.
We provided theoretical model for the eligibility of TMP kinase from Plasmodium falciparum as a new drug target and we confirmed our assumption by experimental trials based on mutational, catalytic and molecular interference assays.
Here we extended our new antimicrobial model to include other blood protozoal infections as anaplasmosis and babesiosis.
Anaplamsa and babesia`s TMP kinase shows important structural differences which can be targeted to develop highly selective antiprotozoal drugs.
Therefore, we estimate that we are able to provide new broad spectrum antiprotozoal capable of binding the more than one parasitic species.
Furthermore, we investigated the inhibitory activity of one new compound capable of inhibiting the Plasmodium TMP kinase.
American Psychological Association (APA)
Qandil, Mahmud& Kitade, Yukio. 2009. Genomic, proteomic and molecular model analyses of tmp kinase from some bloodparasitic protozoa. one-step forward in development of broad spectrum antiprotozoal drugs. Kafr El-Sheikh Veterinary Medical Journal،Vol. 7, no. 1, pp.734-745.
https://search.emarefa.net/detail/BIM-278514
Modern Language Association (MLA)
Qandil, Mahmud& Kitade, Yukio. Genomic, proteomic and molecular model analyses of tmp kinase from some bloodparasitic protozoa. one-step forward in development of broad spectrum antiprotozoal drugs. Kafr El-Sheikh Veterinary Medical Journal Vol. 7, no. 1 (2009), pp.734-745.
https://search.emarefa.net/detail/BIM-278514
American Medical Association (AMA)
Qandil, Mahmud& Kitade, Yukio. Genomic, proteomic and molecular model analyses of tmp kinase from some bloodparasitic protozoa. one-step forward in development of broad spectrum antiprotozoal drugs. Kafr El-Sheikh Veterinary Medical Journal. 2009. Vol. 7, no. 1, pp.734-745.
https://search.emarefa.net/detail/BIM-278514
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 745
Record ID
BIM-278514